Pharmacogenetics-based population pharmacokinetic analysis and dose optimization of valproic acid in Chinese southern children with epilepsy: Effect of ABCB1 gene polymorphism

Pharmacogenetics-based population pharmacokinetic analysis and dose optimization of valproic acid in Chinese southern children with epilepsy: Effect of ABCB1 gene polymorphism

Objective: The aim of this study was to establish a population pharmacokinetic (PPK) model of valproic acid (VPA) in pediatric patients with epilepsy in southern China, and provide guidance for individualized medication of VPA therapy.Methods: A total of 376 VPA steady-state trough concentrations we...

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Bibliographic Details
Main Authors: Xianhuan Shen, Xinyi Chen, Jieluan Lu, Qing Chen, Wenzhou Li, Jiahao Zhu, Yaodong He, Huijuan Guo, Chenshu Xu, Xiaomei Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
valproic acid
epileptic children
population pharmacokinetics
NONMEM
genetic polymorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1037239/full

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