Ascorbate as a cofactor for Fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumour growth and progression

Ascorbate as a cofactor for Fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumour growth and progression

Ascorbate is a specific cofactor for a large family of enzymes known as the Fe- and 2-oxoglutarate-dependent dioxygenases. These enzymes are found throughout biology and catalyse the addition of a hydroxyl group to various substrates. The proline hydroxylase that is involved in collagen maturation...

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Bibliographic Details
Main Authors:	Caroline eKuiper, Margreet C M Vissers
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-12-01
Series:	Frontiers in Oncology
Subjects:	Ascorbic Acid Hydroxylation Hypoxia-Inducible Factor 1 Cancer tumour microenvironment 2-oxoglutarate/Fe(II)-dependent dioxygenase
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00359/full

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