The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats
This study aims to examine the changes of the Ocimum sanctum treatment on the tumor necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β) in the kidney tissue of the rats, in which the experimental diabetes was induced with streptozotocin (STZ). Forty Sprague Dawley male rats were divided into 5...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2021-04-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2795 |
| _version_ | 1797800720006643712 |
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| author | Sevda ELİŞ YILDIZ Buket BAKIR Hasan ASKER Ebru KARADAĞ SARI |
| author_facet | Sevda ELİŞ YILDIZ Buket BAKIR Hasan ASKER Ebru KARADAĞ SARI |
| author_sort | Sevda ELİŞ YILDIZ |
| collection | DOAJ |
| description | This study aims to examine the changes of the Ocimum sanctum treatment on the tumor necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β) in
the kidney tissue of the rats, in which the experimental diabetes was induced with streptozotocin (STZ). Forty Sprague Dawley male rats were divided
into 5 groups: Diabetes, Diabetes + Ocimum sanctum, Ocimum sanctum, Control, and Sham. The immunohistochemical localization of TNF-α and IL-
1β in the kidney tissue was determined by using the streptavidin-biotin-peroxidase method. Strong TNF-α immunoreactivity was determined in the
renal cortex of the rats in the Diabetes and Diabetes + Ocimum sanctum groups on 14th days, low immunoreactivity was determined in the rats in
Ocimum sanctum, Sham, and Control groups. Strong TNF-α immunoreactivity was determined on day 14 in the kidney cortex of rats in the Diabetes
and Diabetes + Ocimum sanctum groups. While strong IL-1β immunoreactivity was observed in the renal cortex of the Diabetes group, moderate IL-1β
immunoreactivity was observed in the renal cortex of the Diabetes + Ocimum sanctum and low immunoreactivity was determined in the Ocimum
sanctum, Sham, and Control groups. In this study, it was assessed how the polymorphisms, occurring in the cytokine genes of Ocimum sanctum in
the rats, in which experimental diabetes was induced, and TNF-α and IL-1β, which was demonstrated to have an important role in the complication
development in the diabetic patients aff ected the renal tissue. |
| first_indexed | 2024-03-13T04:39:32Z |
| format | Article |
| id | doaj.art-9caabf98543b4a97beb56e8574c972da |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:39:32Z |
| publishDate | 2021-04-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-9caabf98543b4a97beb56e8574c972da2023-06-19T06:29:55ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512021-04-0127331532210.9775/kvfd.2021.253592795The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic ratsSevda ELİŞ YILDIZ0Buket BAKIR1Hasan ASKER2Ebru KARADAĞ SARI3Department of Midwifery, Faculty of Health Sciences, Kafkas University, TR-36100 Kars - TURKEYDepartment of Histology and Embryology, Faculty of Veterinary Medicine, Namik Kemal University, TR-59030 Tekirdag, - TURKEYDepartment of Histology and Embryology, Faculty of Medicine, Uşak University, Uşak - TURKEYDepartment of Histology and Embryology, Faculty of Veterinary Medicine, Kafkas University, TR-36040 Kars - TURKEYThis study aims to examine the changes of the Ocimum sanctum treatment on the tumor necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β) in the kidney tissue of the rats, in which the experimental diabetes was induced with streptozotocin (STZ). Forty Sprague Dawley male rats were divided into 5 groups: Diabetes, Diabetes + Ocimum sanctum, Ocimum sanctum, Control, and Sham. The immunohistochemical localization of TNF-α and IL- 1β in the kidney tissue was determined by using the streptavidin-biotin-peroxidase method. Strong TNF-α immunoreactivity was determined in the renal cortex of the rats in the Diabetes and Diabetes + Ocimum sanctum groups on 14th days, low immunoreactivity was determined in the rats in Ocimum sanctum, Sham, and Control groups. Strong TNF-α immunoreactivity was determined on day 14 in the kidney cortex of rats in the Diabetes and Diabetes + Ocimum sanctum groups. While strong IL-1β immunoreactivity was observed in the renal cortex of the Diabetes group, moderate IL-1β immunoreactivity was observed in the renal cortex of the Diabetes + Ocimum sanctum and low immunoreactivity was determined in the Ocimum sanctum, Sham, and Control groups. In this study, it was assessed how the polymorphisms, occurring in the cytokine genes of Ocimum sanctum in the rats, in which experimental diabetes was induced, and TNF-α and IL-1β, which was demonstrated to have an important role in the complication development in the diabetic patients aff ected the renal tissue.https://vetdergikafkas.org/pdf.php?id=2795diabetesocimum sanctumtumor necrosis factor alphainterleukinkidney |
| spellingShingle | Sevda ELİŞ YILDIZ Buket BAKIR Hasan ASKER Ebru KARADAĞ SARI The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats Kafkas Universitesi Veteriner Fakültesi Dergisi diabetes ocimum sanctum tumor necrosis factor alpha interleukin kidney |
| title | The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats |
| title_full | The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats |
| title_fullStr | The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats |
| title_full_unstemmed | The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats |
| title_short | The effects of the basil (ocimum sanctum) treatment on the tumor necrosis factor-α and interleukin 1β release in the kidney tissue of the diabetic rats |
| title_sort | effects of the basil ocimum sanctum treatment on the tumor necrosis factor α and interleukin 1β release in the kidney tissue of the diabetic rats |
| topic | diabetes ocimum sanctum tumor necrosis factor alpha interleukin kidney |
| url | https://vetdergikafkas.org/pdf.php?id=2795 |
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