Computational approaches: discovery of GTPase HRas as prospective drug target for 1,3-diazine scaffolds

Computational approaches: discovery of GTPase HRas as prospective drug target for 1,3-diazine scaffolds

Abstract Heterocyclic 1,3-diazine nucleus is a valuable pharmacophore in the field of medicinal chemistry and exhibit a wide spectrum of biological activities. PharmMapper, a robust online tool used for establishing the target proteins based on reverse pharmacophore mapping. PharmMapper study is car...

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Bibliographic Details
Main Authors: Sanjiv Kumar, Deepika Sharma, Balasubramanian Narasimhan, Kalavathy Ramasamy, Syed Adnan Ali Shah, Siong Meng Lim, Vasudevan Mani
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Chemistry
Subjects:
PharmMapper
1,3-Diazines
GTPase HRas
Docking
HCT116 cancer cell
Online Access:http://link.springer.com/article/10.1186/s13065-019-0613-8

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