Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy
Abstract Background Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including an explicitly derived arterial input function (AIF) for each tracer usi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-02-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-020-0277-4 |
| _version_ | 1818661762017263616 |
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| author | Carlos Velasco Adriana Mota-Cobián Jesús Mateo Samuel España |
| author_facet | Carlos Velasco Adriana Mota-Cobián Jesús Mateo Samuel España |
| author_sort | Carlos Velasco |
| collection | DOAJ |
| description | Abstract Background Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including an explicitly derived arterial input function (AIF) for each tracer using blood sampling spectroscopy. For that purpose, at least one of the co-injected tracers must be based on a non-pure positron emitter. Methods The proposed technique was validated in vivo by performing cardiac PET/CT studies on three healthy pigs injected with 18FDG (viability) and 68Ga-DOTA (myocardial blood flow and extracellular volume fraction) during the same acquisition. Blood samples were collected during the PET scan, and separated AIF for each tracer was obtained by spectroscopic analysis. A multi-tracer compartment model was applied to the myocardium in order to obtain the distribution of each tracer at the end of the PET scan. Relative activities of both tracers and tracer uptake were obtained and compared with the values obtained by ex vivo analysis of excised myocardial tissue segments. Results A high correlation was obtained between multi-tracer PET results, and those obtained from ex vivo analysis (18FDG relative activity: r = 0.95, p < 0.0001; SUV: r = 0.98, p < 0.0001). Conclusions The proposed technique allows performing PET scans with two tracers during the same acquisition obtaining separate information for each tracer. |
| first_indexed | 2024-12-17T04:50:12Z |
| format | Article |
| id | doaj.art-9caf47eb3fa241bfbcf2f602bc23c89c |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-12-17T04:50:12Z |
| publishDate | 2020-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-9caf47eb3fa241bfbcf2f602bc23c89c2022-12-21T22:02:55ZengSpringerOpenEJNMMI Physics2197-73642020-02-017111510.1186/s40658-020-0277-4Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopyCarlos Velasco0Adriana Mota-Cobián1Jesús Mateo2Samuel España3Centro Nacional de Investigaciones Cardiovasculares (CNIC)Centro Nacional de Investigaciones Cardiovasculares (CNIC)Centro Nacional de Investigaciones Cardiovasculares (CNIC)Centro Nacional de Investigaciones Cardiovasculares (CNIC)Abstract Background Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including an explicitly derived arterial input function (AIF) for each tracer using blood sampling spectroscopy. For that purpose, at least one of the co-injected tracers must be based on a non-pure positron emitter. Methods The proposed technique was validated in vivo by performing cardiac PET/CT studies on three healthy pigs injected with 18FDG (viability) and 68Ga-DOTA (myocardial blood flow and extracellular volume fraction) during the same acquisition. Blood samples were collected during the PET scan, and separated AIF for each tracer was obtained by spectroscopic analysis. A multi-tracer compartment model was applied to the myocardium in order to obtain the distribution of each tracer at the end of the PET scan. Relative activities of both tracers and tracer uptake were obtained and compared with the values obtained by ex vivo analysis of excised myocardial tissue segments. Results A high correlation was obtained between multi-tracer PET results, and those obtained from ex vivo analysis (18FDG relative activity: r = 0.95, p < 0.0001; SUV: r = 0.98, p < 0.0001). Conclusions The proposed technique allows performing PET scans with two tracers during the same acquisition obtaining separate information for each tracer.https://doi.org/10.1186/s40658-020-0277-4Arterial input functionPositron emission tomographyMulti-tracer PETGamma spectroscopy |
| spellingShingle | Carlos Velasco Adriana Mota-Cobián Jesús Mateo Samuel España Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy EJNMMI Physics Arterial input function Positron emission tomography Multi-tracer PET Gamma spectroscopy |
| title | Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy |
| title_full | Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy |
| title_fullStr | Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy |
| title_full_unstemmed | Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy |
| title_short | Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy |
| title_sort | explicit measurement of multi tracer arterial input function for pet imaging using blood sampling spectroscopy |
| topic | Arterial input function Positron emission tomography Multi-tracer PET Gamma spectroscopy |
| url | https://doi.org/10.1186/s40658-020-0277-4 |
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