Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid
Piezoelectric quartz crystals and analogous gold substrates were electrochemically coated with molecularly imprinted polypyrrole films for pulsed amperometric detection (PAD) of clofibric acid, a metabolite of clofibrate. Cyclic voltammetry data obtained during polymerization and deposited weight es...
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MDPI AG
2015-02-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/15/3/4870 |
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| author | Bianca Schweiger Jungtae Kim Young Jun Kim Mathias Ulbricht |
| author_facet | Bianca Schweiger Jungtae Kim Young Jun Kim Mathias Ulbricht |
| author_sort | Bianca Schweiger |
| collection | DOAJ |
| description | Piezoelectric quartz crystals and analogous gold substrates were electrochemically coated with molecularly imprinted polypyrrole films for pulsed amperometric detection (PAD) of clofibric acid, a metabolite of clofibrate. Cyclic voltammetry data obtained during polymerization and deposited weight estimations revealed a decrease of the polymerization rate with increasing clofibric acid concentration. XPS measurements indicated that clofibric acid could be removed after imprinting with an aqueous ethanol solution, which was further optimized by using PAD. Zeta potential and contact angle measurements revealed differences between molecularly imprinted (MIP) and non-imprinted polymer (NIP) layers. Binding experiments with clofibric acid and other substances showed a pronounced selectivity of the MIP for clofibric acid vs. carbamazepine, but the response of MIP and NIP to 2,4-dichlorophenoxyacetic acid was higher than that for clofibric acid. A smooth surface, revealed by AFM measurements, with roughness of 6–8 nm for imprinted and non-imprinted layers, might be a reason for an excessively low density of specific binding sites for clofibric acid. Furthermore, the decreased polymerization rate in the presence of clofibric acid might not result in well-defined polymer structures, which could be the reason for the lower sensitivity. |
| first_indexed | 2024-04-11T13:18:17Z |
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| id | doaj.art-9cb01f56d1d44bd8ab5c138c3649745f |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T13:18:17Z |
| publishDate | 2015-02-01 |
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| series | Sensors |
| spelling | doaj.art-9cb01f56d1d44bd8ab5c138c3649745f2022-12-22T04:22:19ZengMDPI AGSensors1424-82202015-02-011534870488910.3390/s150304870s150304870Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric AcidBianca Schweiger0Jungtae Kim1Young Jun Kim2Mathias Ulbricht3KIST Europe Forschungsgesellschaft mbH, Campus E 7.1, 66123 Saarbrücken, GermanyKIST Europe Forschungsgesellschaft mbH, Campus E 7.1, 66123 Saarbrücken, GermanyKIST Europe Forschungsgesellschaft mbH, Campus E 7.1, 66123 Saarbrücken, GermanyLehrstuhl für Technische Chemie II, Universität Duisburg-Essen, Universitätsstraße 7, 45141 Essen, GermanyPiezoelectric quartz crystals and analogous gold substrates were electrochemically coated with molecularly imprinted polypyrrole films for pulsed amperometric detection (PAD) of clofibric acid, a metabolite of clofibrate. Cyclic voltammetry data obtained during polymerization and deposited weight estimations revealed a decrease of the polymerization rate with increasing clofibric acid concentration. XPS measurements indicated that clofibric acid could be removed after imprinting with an aqueous ethanol solution, which was further optimized by using PAD. Zeta potential and contact angle measurements revealed differences between molecularly imprinted (MIP) and non-imprinted polymer (NIP) layers. Binding experiments with clofibric acid and other substances showed a pronounced selectivity of the MIP for clofibric acid vs. carbamazepine, but the response of MIP and NIP to 2,4-dichlorophenoxyacetic acid was higher than that for clofibric acid. A smooth surface, revealed by AFM measurements, with roughness of 6–8 nm for imprinted and non-imprinted layers, might be a reason for an excessively low density of specific binding sites for clofibric acid. Furthermore, the decreased polymerization rate in the presence of clofibric acid might not result in well-defined polymer structures, which could be the reason for the lower sensitivity.http://www.mdpi.com/1424-8220/15/3/4870molecularly imprinted polymerpolypyrroleclofibric acidquartz crystal microbalanceelectrochemical polymerizationamperometric sensor |
| spellingShingle | Bianca Schweiger Jungtae Kim Young Jun Kim Mathias Ulbricht Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid Sensors molecularly imprinted polymer polypyrrole clofibric acid quartz crystal microbalance electrochemical polymerization amperometric sensor |
| title | Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid |
| title_full | Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid |
| title_fullStr | Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid |
| title_full_unstemmed | Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid |
| title_short | Electropolymerized Molecularly Imprinted Polypyrrole Film for Sensing of Clofibric Acid |
| title_sort | electropolymerized molecularly imprinted polypyrrole film for sensing of clofibric acid |
| topic | molecularly imprinted polymer polypyrrole clofibric acid quartz crystal microbalance electrochemical polymerization amperometric sensor |
| url | http://www.mdpi.com/1424-8220/15/3/4870 |
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