Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine

Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine

Objective: To evaluate drug-drug interactions (DDIs) between gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs). Methods: In vitro supersomes were used to identify CYP isoenzymes (CYP1A2, 2C9, 2C19, 2D6, and 3A4) involved in drug metabolism, and in vitro pooled cryop...

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Bibliographic Details
Main Authors: Thu-Lan T. Luong, Chelsea N. Powers, Brian J. Reinhardt, Peter J. Weina
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Drug-drug interactions
Cytochrome P450
Gefitinib
Selective serotonin reuptake inhibitors (SSRIs) (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine)
Losartan
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257122000323

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