<em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives
The selection of the best alternative for <i>Enterococcus faecalis</i> infective endocarditis (IE) continuation treatment in the outpatient setting is still challenging. Three databases were searched, reporting antibiotic therapies against <i>E. faecalis</i> IE in or suitable...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/10/657 |
| _version_ | 1827705138576359424 |
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| author | Laura Herrera-Hidalgo Arístides de Alarcón Luis E. López-Cortes Rafael Luque-Márquez Luis F. López-Cortes Alicia Gutiérrez-Valencia María V. Gil-Navarro |
| author_facet | Laura Herrera-Hidalgo Arístides de Alarcón Luis E. López-Cortes Rafael Luque-Márquez Luis F. López-Cortes Alicia Gutiérrez-Valencia María V. Gil-Navarro |
| author_sort | Laura Herrera-Hidalgo |
| collection | DOAJ |
| description | The selection of the best alternative for <i>Enterococcus faecalis</i> infective endocarditis (IE) continuation treatment in the outpatient setting is still challenging. Three databases were searched, reporting antibiotic therapies against <i>E. faecalis</i> IE in or suitable for the outpatient setting. Articles the results of which were identified by species and treatment regimen were included. The quality of the studies was assessed accordingly with the study design. Data were extracted and synthesized narratively. In total, 18 studies were included. The treatment regimens reported were classified regarding the main antibiotic used as regimen, based on Aminoglycosides, dual β-lactam, teicoplanin, daptomycin or dalbavancin or oral therapy. The regimens based on aminoglycosides and dual β-lactam combinations are the treatment alternatives which gather more evidence regarding their efficacy. Dual β-lactam is the preferred option for high level aminoglycoside resistance strains, and for to its reduced nephrotoxicity, while its adaptation to the outpatient setting has been poorly documented. Less evidence supports the remaining alternatives, but many of them have been successfully adapted to outpatient care. Teicoplanin and dalbavancin as well as oral therapy seem promising. Our work provides an extensive examination of the potential alternatives to <i>E. faecalis</i> IE useful for outpatient care. However, the insufficient evidence hampers the attempt to give a general recommendation. |
| first_indexed | 2024-03-10T15:57:01Z |
| format | Article |
| id | doaj.art-9cb1156d2bcb43c7bdcb3c4d2cb2b01c |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T15:57:01Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-9cb1156d2bcb43c7bdcb3c4d2cb2b01c2023-11-20T15:36:40ZengMDPI AGAntibiotics2079-63822020-09-0191065710.3390/antibiotics9100657<em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current AlternativesLaura Herrera-Hidalgo0Arístides de Alarcón1Luis E. López-Cortes2Rafael Luque-Márquez3Luis F. López-Cortes4Alicia Gutiérrez-Valencia5María V. Gil-Navarro6Unidad de Gestión Clinica de Farmacia, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), 41009 Seville, SpainUnidad de Gestión Clinica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), 41009 Seville, SpainUnidad de Gestión Clinica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena/CSIC/Instituto de Biomedicina de Sevilla (IBiS), 41009 Seville, SpainUnidad de Gestión Clinica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), 41009 Seville, SpainUnidad de Gestión Clinica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), 41009 Seville, SpainUnidad de Gestión Clinica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), 41009 Seville, SpainUnidad de Gestión Clinica de Farmacia, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), 41009 Seville, SpainThe selection of the best alternative for <i>Enterococcus faecalis</i> infective endocarditis (IE) continuation treatment in the outpatient setting is still challenging. Three databases were searched, reporting antibiotic therapies against <i>E. faecalis</i> IE in or suitable for the outpatient setting. Articles the results of which were identified by species and treatment regimen were included. The quality of the studies was assessed accordingly with the study design. Data were extracted and synthesized narratively. In total, 18 studies were included. The treatment regimens reported were classified regarding the main antibiotic used as regimen, based on Aminoglycosides, dual β-lactam, teicoplanin, daptomycin or dalbavancin or oral therapy. The regimens based on aminoglycosides and dual β-lactam combinations are the treatment alternatives which gather more evidence regarding their efficacy. Dual β-lactam is the preferred option for high level aminoglycoside resistance strains, and for to its reduced nephrotoxicity, while its adaptation to the outpatient setting has been poorly documented. Less evidence supports the remaining alternatives, but many of them have been successfully adapted to outpatient care. Teicoplanin and dalbavancin as well as oral therapy seem promising. Our work provides an extensive examination of the potential alternatives to <i>E. faecalis</i> IE useful for outpatient care. However, the insufficient evidence hampers the attempt to give a general recommendation.https://www.mdpi.com/2079-6382/9/10/657<i>Enterococcus faecalis</i>infective endocarditisoutpatient treatmentoutpatient parenteral antibiotic treatment (OPAT)systematic reviewtreatment alternatives |
| spellingShingle | Laura Herrera-Hidalgo Arístides de Alarcón Luis E. López-Cortes Rafael Luque-Márquez Luis F. López-Cortes Alicia Gutiérrez-Valencia María V. Gil-Navarro <em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives Antibiotics <i>Enterococcus faecalis</i> infective endocarditis outpatient treatment outpatient parenteral antibiotic treatment (OPAT) systematic review treatment alternatives |
| title | <em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives |
| title_full | <em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives |
| title_fullStr | <em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives |
| title_full_unstemmed | <em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives |
| title_short | <em>Enterococcus faecalis</em> Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives |
| title_sort | em enterococcus faecalis em endocarditis and outpatient treatment a systematic review of current alternatives |
| topic | <i>Enterococcus faecalis</i> infective endocarditis outpatient treatment outpatient parenteral antibiotic treatment (OPAT) systematic review treatment alternatives |
| url | https://www.mdpi.com/2079-6382/9/10/657 |
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