Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring
Most meningiomas are slow growing tumors arising from the arachnoid cap cells and can be cured by surgical resection or radiation therapy in selected cases. However, recurrent and aggressive cases are also quite common and challenging to treat due to no established treatment alternatives. Assessment...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/13/3259 |
| _version_ | 1797528410693566464 |
|---|---|
| author | Felix Behling Johann-Martin Hempel Jens Schittenhelm |
| author_facet | Felix Behling Johann-Martin Hempel Jens Schittenhelm |
| author_sort | Felix Behling |
| collection | DOAJ |
| description | Most meningiomas are slow growing tumors arising from the arachnoid cap cells and can be cured by surgical resection or radiation therapy in selected cases. However, recurrent and aggressive cases are also quite common and challenging to treat due to no established treatment alternatives. Assessment of the risk of recurrence is therefore of utmost importance and several prognostic clinical and molecular markers have been established. Additionally, the identification of invasive growth of meningioma cells into CNS tissue was demonstrated to lead to a higher risk of recurrence and was therefore integrated into the WHO classification of CNS tumors. However, the evidence for its prognostic impact has been questioned in subsequent studies and its exclusion from the next WHO classification proposed. We were recently able to show the prognostic impact of CNS invasion in a large comprehensive retrospective meningioma cohort including other established prognostic factors. In this review we discuss the growing experiences that have been gained on this matter, with a focus on the currently nonuniform histopathological assessment, imaging characteristics and intraoperative sampling as well as the overall outlook on the future role of this potential prognostic factor. |
| first_indexed | 2024-03-10T09:57:58Z |
| format | Article |
| id | doaj.art-9cb164df4f3b4fcfaa05a8cdc3c1d56b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:57:58Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9cb164df4f3b4fcfaa05a8cdc3c1d56b2023-11-22T02:12:33ZengMDPI AGCancers2072-66942021-06-011313325910.3390/cancers13133259Brain Invasion in Meningioma—A Prognostic Potential Worth ExploringFelix Behling0Johann-Martin Hempel1Jens Schittenhelm2Department of Neurosurgery, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, GermanyCenter for CNS Tumors, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, GermanyCenter for CNS Tumors, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, GermanyMost meningiomas are slow growing tumors arising from the arachnoid cap cells and can be cured by surgical resection or radiation therapy in selected cases. However, recurrent and aggressive cases are also quite common and challenging to treat due to no established treatment alternatives. Assessment of the risk of recurrence is therefore of utmost importance and several prognostic clinical and molecular markers have been established. Additionally, the identification of invasive growth of meningioma cells into CNS tissue was demonstrated to lead to a higher risk of recurrence and was therefore integrated into the WHO classification of CNS tumors. However, the evidence for its prognostic impact has been questioned in subsequent studies and its exclusion from the next WHO classification proposed. We were recently able to show the prognostic impact of CNS invasion in a large comprehensive retrospective meningioma cohort including other established prognostic factors. In this review we discuss the growing experiences that have been gained on this matter, with a focus on the currently nonuniform histopathological assessment, imaging characteristics and intraoperative sampling as well as the overall outlook on the future role of this potential prognostic factor.https://www.mdpi.com/2072-6694/13/13/3259meningiomainvasive growthbrain invasionprognosisrecurrenceWHO classification for CNS tumors |
| spellingShingle | Felix Behling Johann-Martin Hempel Jens Schittenhelm Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring Cancers meningioma invasive growth brain invasion prognosis recurrence WHO classification for CNS tumors |
| title | Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring |
| title_full | Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring |
| title_fullStr | Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring |
| title_full_unstemmed | Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring |
| title_short | Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring |
| title_sort | brain invasion in meningioma a prognostic potential worth exploring |
| topic | meningioma invasive growth brain invasion prognosis recurrence WHO classification for CNS tumors |
| url | https://www.mdpi.com/2072-6694/13/13/3259 |
| work_keys_str_mv | AT felixbehling braininvasioninmeningiomaaprognosticpotentialworthexploring AT johannmartinhempel braininvasioninmeningiomaaprognosticpotentialworthexploring AT jensschittenhelm braininvasioninmeningiomaaprognosticpotentialworthexploring |