Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients
Abstract Oxidative stress had been linked to hypertensive renal impairment in previous investigations. Superoxide dismutase (SOD) was a clinically available oxidative stress biomarker. The association between SOD and the microalbuminuria in hypertensive patients has not been established. From Januar...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-24804-3 |
| _version_ | 1811190415963979776 |
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| author | Xiaoqian Yu Rui Xu Wen Huang Lin Lin Fei Zheng Xia Wu |
| author_facet | Xiaoqian Yu Rui Xu Wen Huang Lin Lin Fei Zheng Xia Wu |
| author_sort | Xiaoqian Yu |
| collection | DOAJ |
| description | Abstract Oxidative stress had been linked to hypertensive renal impairment in previous investigations. Superoxide dismutase (SOD) was a clinically available oxidative stress biomarker. The association between SOD and the microalbuminuria in hypertensive patients has not been established. From January 2017 to December 2018, data on 690 patients with essential hypertension were collected retrospectively at Shandong Provincial Qianfoshan Hospital. Patients were divided into hypertension with microalbuminuria group (HM) and hypertension without microalbuminuria group (NHM). Clinical data from patients were collected and compared between the two groups. Spearman correlation analysis was used to analyze the correlation between UACR and SOD. Univariate and multivariate logistic regression analyses were used to screen for the risk factors for HM. Our research included 556 patients in the NHM group and 134 patients in the HM group. Spearman correlation analysis showed a negative correlation between SOD and UACR (P < 0.001). Multivariate logistic regression analysis showed SOD was an independent protective factor in hypertensive patients with HM. In hypertensive patients, a substantial, negative correlation between SOD and early renal damage was found, suggesting that SOD may protect renal function. |
| first_indexed | 2024-04-11T14:50:52Z |
| format | Article |
| id | doaj.art-9cb2bf6554bd4e5abaa2f9914da72a18 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T14:50:52Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9cb2bf6554bd4e5abaa2f9914da72a182022-12-22T04:17:28ZengNature PortfolioScientific Reports2045-23222022-11-011211710.1038/s41598-022-24804-3Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patientsXiaoqian Yu0Rui Xu1Wen Huang2Lin Lin3Fei Zheng4Xia Wu5Department of Cardiology, Jinan Central Hospital, Shandong UniversityDepartment of Cardiology, Central Hospital Affiliated to Shandong First Medical UniversityDepartment of Medical Ultrasound, The First Affiliated Hospital of Shandong First Medical UniversityDepartment of Cardiology, Liaocheng People’s HospitalDepartment of Cardiology, The First Affiliated Hospital of Shandong First Medical UniversityDepartment of Rehabilitation Medicine, The Second Hospital of Shandong UniversityAbstract Oxidative stress had been linked to hypertensive renal impairment in previous investigations. Superoxide dismutase (SOD) was a clinically available oxidative stress biomarker. The association between SOD and the microalbuminuria in hypertensive patients has not been established. From January 2017 to December 2018, data on 690 patients with essential hypertension were collected retrospectively at Shandong Provincial Qianfoshan Hospital. Patients were divided into hypertension with microalbuminuria group (HM) and hypertension without microalbuminuria group (NHM). Clinical data from patients were collected and compared between the two groups. Spearman correlation analysis was used to analyze the correlation between UACR and SOD. Univariate and multivariate logistic regression analyses were used to screen for the risk factors for HM. Our research included 556 patients in the NHM group and 134 patients in the HM group. Spearman correlation analysis showed a negative correlation between SOD and UACR (P < 0.001). Multivariate logistic regression analysis showed SOD was an independent protective factor in hypertensive patients with HM. In hypertensive patients, a substantial, negative correlation between SOD and early renal damage was found, suggesting that SOD may protect renal function.https://doi.org/10.1038/s41598-022-24804-3 |
| spellingShingle | Xiaoqian Yu Rui Xu Wen Huang Lin Lin Fei Zheng Xia Wu Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients Scientific Reports |
| title | Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients |
| title_full | Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients |
| title_fullStr | Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients |
| title_full_unstemmed | Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients |
| title_short | Superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients |
| title_sort | superoxide dismutase as a protective factor for microalbuminuria in hypertensive patients |
| url | https://doi.org/10.1038/s41598-022-24804-3 |
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