Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism

Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism

Abstract Background Polymorphisms in MTHFR gene influence risk and overall survival of patients with brain tumor. Global genomic DNA (gDNA) methylation profile from tumor tissues is replicated in peripheral leukocytes. This study aimed to draw a correlation between rs1801133 MTHFR variants, gDNA met...

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Bibliographic Details
Main Authors: Giselle M. Faria, Igor D. P. Soares, Marcela D’Alincourt Salazar, Marcia R. Amorim, Bruno L. Pessoa, Clovis O. da Fonseca, Thereza Quirico-Santos
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Cancer
Subjects:
Perillyl alcohol
Glioblastoma
Methylation
Polymorphism
MTHFR
Epigenetics
Online Access:http://link.springer.com/article/10.1186/s12885-020-06802-8

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