Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer
Breast and prostate cancer are the second and third leading causes of death amongst all cancer types, respectively. Pathogenesis of these malignancies is characterised by dysregulation of sex hormone signalling pathways, mediated by the estrogen receptor-α (ER) in breast cancer and androgen receptor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/13/3254 |
| _version_ | 1797528410909573120 |
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| author | Jianling Xie Eric P. Kusnadi Luc Furic Luke A. Selth |
| author_facet | Jianling Xie Eric P. Kusnadi Luc Furic Luke A. Selth |
| author_sort | Jianling Xie |
| collection | DOAJ |
| description | Breast and prostate cancer are the second and third leading causes of death amongst all cancer types, respectively. Pathogenesis of these malignancies is characterised by dysregulation of sex hormone signalling pathways, mediated by the estrogen receptor-α (ER) in breast cancer and androgen receptor (AR) in prostate cancer. ER and AR are transcription factors whose aberrant function drives oncogenic transcriptional programs to promote cancer growth and progression. While ER/AR are known to stimulate cell growth and survival by modulating gene transcription, emerging findings indicate that their effects in neoplasia are also mediated by dysregulation of protein synthesis (i.e., mRNA translation). This suggests that ER/AR can coordinately perturb both transcriptional and translational programs, resulting in the establishment of proteomes that promote malignancy. In this review, we will discuss relatively understudied aspects of ER and AR activity in regulating protein synthesis as well as the potential of targeting mRNA translation in breast and prostate cancer. |
| first_indexed | 2024-03-10T09:57:58Z |
| format | Article |
| id | doaj.art-9cb5b5bc4b0a4bf3992bda35276de58a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:57:58Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9cb5b5bc4b0a4bf3992bda35276de58a2023-11-22T02:11:39ZengMDPI AGCancers2072-66942021-06-011313325410.3390/cancers13133254Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate CancerJianling Xie0Eric P. Kusnadi1Luc Furic2Luke A. Selth3Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, AustraliaTranslational Prostate Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, AustraliaTranslational Prostate Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, AustraliaFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, AustraliaBreast and prostate cancer are the second and third leading causes of death amongst all cancer types, respectively. Pathogenesis of these malignancies is characterised by dysregulation of sex hormone signalling pathways, mediated by the estrogen receptor-α (ER) in breast cancer and androgen receptor (AR) in prostate cancer. ER and AR are transcription factors whose aberrant function drives oncogenic transcriptional programs to promote cancer growth and progression. While ER/AR are known to stimulate cell growth and survival by modulating gene transcription, emerging findings indicate that their effects in neoplasia are also mediated by dysregulation of protein synthesis (i.e., mRNA translation). This suggests that ER/AR can coordinately perturb both transcriptional and translational programs, resulting in the establishment of proteomes that promote malignancy. In this review, we will discuss relatively understudied aspects of ER and AR activity in regulating protein synthesis as well as the potential of targeting mRNA translation in breast and prostate cancer.https://www.mdpi.com/2072-6694/13/13/3254androgen receptorbreast cancerestrogen receptormRNA translationmTORprostate cancer |
| spellingShingle | Jianling Xie Eric P. Kusnadi Luc Furic Luke A. Selth Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer Cancers androgen receptor breast cancer estrogen receptor mRNA translation mTOR prostate cancer |
| title | Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer |
| title_full | Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer |
| title_fullStr | Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer |
| title_full_unstemmed | Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer |
| title_short | Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer |
| title_sort | regulation of mrna translation by hormone receptors in breast and prostate cancer |
| topic | androgen receptor breast cancer estrogen receptor mRNA translation mTOR prostate cancer |
| url | https://www.mdpi.com/2072-6694/13/13/3254 |
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