Oxygen in interstitial lung diseases
Domiciliary oxygen is essential in the care of hypoxaemic interstitial lung disease (ILD) patients. Guidelines concur in advising prescription of long-term oxygen therapy (LTOT) for ILD patients with severe hypoxaemia at rest, in view of its beneficial impact on breathlessness/disability and extrapo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2023-03-01
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| Series: | Breathe |
| Online Access: | http://breathe.ersjournals.com/content/19/1/220271.full |
| _version_ | 1797810128990240768 |
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| author | Ricardo Cordeiro André Nunes Oliver Smith Elisabetta A. Renzoni |
| author_facet | Ricardo Cordeiro André Nunes Oliver Smith Elisabetta A. Renzoni |
| author_sort | Ricardo Cordeiro |
| collection | DOAJ |
| description | Domiciliary oxygen is essential in the care of hypoxaemic interstitial lung disease (ILD) patients. Guidelines concur in advising prescription of long-term oxygen therapy (LTOT) for ILD patients with severe hypoxaemia at rest, in view of its beneficial impact on breathlessness/disability and extrapolating potential survival benefits seen in COPD patients. A less severe hypoxaemia threshold for initiation of LTOT is recommended for patients with pulmonary hypertension (PH)/right heart failure, requiring careful evaluation in all ILD patients. In light of evidence suggesting a link between nocturnal hypoxaemia, development of PH and poor survival, studies assessing the impact of nocturnal oxygen are urgently needed. Severe exertional hypoxaemia is frequent in ILD patients, with impact on exercise tolerance, quality of life and mortality. Ambulatory oxygen therapy (AOT) has been associated with improvement in breathlessness and quality of life in ILD patients with exertional hypoxaemia. However, given the paucity of evidence, not all current AOT guidelines are in agreement. Ongoing clinical trials will provide further useful data. Despite its beneficial effects, supplemental oxygen imposes burdens and challenges to patients. A key unmet area of need is the development of less cumbersome and more efficient oxygen delivery systems to reduce the negative impact of AOT on patients' lives. |
| first_indexed | 2024-03-13T07:04:39Z |
| format | Article |
| id | doaj.art-9cb6e026c397467e928768f5486bd58a |
| institution | Directory Open Access Journal |
| issn | 1810-6838 2073-4735 |
| language | English |
| last_indexed | 2024-03-13T07:04:39Z |
| publishDate | 2023-03-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | Breathe |
| spelling | doaj.art-9cb6e026c397467e928768f5486bd58a2023-06-06T14:23:00ZengEuropean Respiratory SocietyBreathe1810-68382073-47352023-03-0119110.1183/20734735.0271-20220271-2022Oxygen in interstitial lung diseasesRicardo Cordeiro0André Nunes1Oliver Smith2Elisabetta A. Renzoni3 Centro de Responsabilidade Integrada de Pneumologia, Hospital de Torres Vedras, Centro Hospitalar do Oeste, Torres Vedras, Portugal Centro de Responsabilidade Integrada de Pneumologia, Hospital de Torres Vedras, Centro Hospitalar do Oeste, Torres Vedras, Portugal Rehabilitation and Therapies Directorate, Royal Brompton Hospital, London, UK Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK Domiciliary oxygen is essential in the care of hypoxaemic interstitial lung disease (ILD) patients. Guidelines concur in advising prescription of long-term oxygen therapy (LTOT) for ILD patients with severe hypoxaemia at rest, in view of its beneficial impact on breathlessness/disability and extrapolating potential survival benefits seen in COPD patients. A less severe hypoxaemia threshold for initiation of LTOT is recommended for patients with pulmonary hypertension (PH)/right heart failure, requiring careful evaluation in all ILD patients. In light of evidence suggesting a link between nocturnal hypoxaemia, development of PH and poor survival, studies assessing the impact of nocturnal oxygen are urgently needed. Severe exertional hypoxaemia is frequent in ILD patients, with impact on exercise tolerance, quality of life and mortality. Ambulatory oxygen therapy (AOT) has been associated with improvement in breathlessness and quality of life in ILD patients with exertional hypoxaemia. However, given the paucity of evidence, not all current AOT guidelines are in agreement. Ongoing clinical trials will provide further useful data. Despite its beneficial effects, supplemental oxygen imposes burdens and challenges to patients. A key unmet area of need is the development of less cumbersome and more efficient oxygen delivery systems to reduce the negative impact of AOT on patients' lives.http://breathe.ersjournals.com/content/19/1/220271.full |
| spellingShingle | Ricardo Cordeiro André Nunes Oliver Smith Elisabetta A. Renzoni Oxygen in interstitial lung diseases Breathe |
| title | Oxygen in interstitial lung diseases |
| title_full | Oxygen in interstitial lung diseases |
| title_fullStr | Oxygen in interstitial lung diseases |
| title_full_unstemmed | Oxygen in interstitial lung diseases |
| title_short | Oxygen in interstitial lung diseases |
| title_sort | oxygen in interstitial lung diseases |
| url | http://breathe.ersjournals.com/content/19/1/220271.full |
| work_keys_str_mv | AT ricardocordeiro oxygenininterstitiallungdiseases AT andrenunes oxygenininterstitiallungdiseases AT oliversmith oxygenininterstitiallungdiseases AT elisabettaarenzoni oxygenininterstitiallungdiseases |