GSTP1 as a novel target in radiation induced lung injury
Abstract The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is closely related to the regulation of cell oxidative stress, inhibition of cell apopto...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-021-02978-0 |
| _version_ | 1818665431314989056 |
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| author | Xiao Lei Lehui Du Wei Yu Yao Wang Na Ma Baolin Qu |
| author_facet | Xiao Lei Lehui Du Wei Yu Yao Wang Na Ma Baolin Qu |
| author_sort | Xiao Lei |
| collection | DOAJ |
| description | Abstract The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is closely related to the regulation of cell oxidative stress, inhibition of cell apoptosis and promotion of cytotoxic metabolism. Interestingly, there is evidence that GSTP1 single nucleotide polymorphisms (SNP) 105Ile/Val related to the risk of radiation induced lung injury (RILI) development, which strongly suggests that GSTP1 is closely associated with the occurrence and development of RILI. In this review, we discuss our understanding of the role of GSTP1 in RILI and its possible mechanism. |
| first_indexed | 2024-12-17T05:48:31Z |
| format | Article |
| id | doaj.art-9cb725e98c9049aea9c7e9a6db589b89 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-17T05:48:31Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-9cb725e98c9049aea9c7e9a6db589b892022-12-21T22:01:13ZengBMCJournal of Translational Medicine1479-58762021-07-011911510.1186/s12967-021-02978-0GSTP1 as a novel target in radiation induced lung injuryXiao Lei0Lehui Du1Wei Yu2Yao Wang3Na Ma4Baolin Qu5Department of Radiation Oncology, The Fifth Medical Center of the Chinese PLA General HospitalDepartment of Radiation Oncology, The Fifth Medical Center of the Chinese PLA General HospitalDepartment of Radiation Oncology, The Fifth Medical Center of the Chinese PLA General HospitalDepartment of Radiation Oncology, The Fifth Medical Center of the Chinese PLA General HospitalDepartment of Radiation Oncology, The Fifth Medical Center of the Chinese PLA General HospitalDepartment of Radiation Oncology, The Fifth Medical Center of the Chinese PLA General HospitalAbstract The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is closely related to the regulation of cell oxidative stress, inhibition of cell apoptosis and promotion of cytotoxic metabolism. Interestingly, there is evidence that GSTP1 single nucleotide polymorphisms (SNP) 105Ile/Val related to the risk of radiation induced lung injury (RILI) development, which strongly suggests that GSTP1 is closely associated with the occurrence and development of RILI. In this review, we discuss our understanding of the role of GSTP1 in RILI and its possible mechanism.https://doi.org/10.1186/s12967-021-02978-0Radiation induced lung injuryGSTP1Inflammatory responseFibrosis |
| spellingShingle | Xiao Lei Lehui Du Wei Yu Yao Wang Na Ma Baolin Qu GSTP1 as a novel target in radiation induced lung injury Journal of Translational Medicine Radiation induced lung injury GSTP1 Inflammatory response Fibrosis |
| title | GSTP1 as a novel target in radiation induced lung injury |
| title_full | GSTP1 as a novel target in radiation induced lung injury |
| title_fullStr | GSTP1 as a novel target in radiation induced lung injury |
| title_full_unstemmed | GSTP1 as a novel target in radiation induced lung injury |
| title_short | GSTP1 as a novel target in radiation induced lung injury |
| title_sort | gstp1 as a novel target in radiation induced lung injury |
| topic | Radiation induced lung injury GSTP1 Inflammatory response Fibrosis |
| url | https://doi.org/10.1186/s12967-021-02978-0 |
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