Innate lymphoid cells in depression: Current status and perspectives
The recent discovery of innate lymphoid cells (ILCs) has provided new insights into our understanding of the pathogenesis of many disease conditions with immune dysregulation. Type 1 innate lymphoid cells (ILC1s) induce type I immunity and are characterized by the expression of signature cytokine IF...
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Format: | Article |
Language: | English |
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Elsevier
2022-12-01
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Series: | Biomarkers in Neuropsychiatry |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2666144622000107 |
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author | Amit Kumar Madeshiya Anilkumar Pillai |
author_facet | Amit Kumar Madeshiya Anilkumar Pillai |
author_sort | Amit Kumar Madeshiya |
collection | DOAJ |
description | The recent discovery of innate lymphoid cells (ILCs) has provided new insights into our understanding of the pathogenesis of many disease conditions with immune dysregulation. Type 1 innate lymphoid cells (ILC1s) induce type I immunity and are characterized by the expression of signature cytokine IFN-γ and the master transcription factor T-bet; ILC2s stimulate type II immune responses and are defined by the expression of signature cytokines IL-5 and IL-13, and transcription factors ROR-α and GATA3; ILC3s requires the transcription factor RORγt and produce IL-22 and IL-17. ILCs are largely tissue-resident and are enriched at barrier surfaces of the mammalian body. Increasing evidence shows that inflammation is involved in the pathogenesis of depression. Although few studies have directly investigated the role of ILCs in depression, several studies have examined the levels of cytokines produced by ILCs in depressed subjects. This review summarizes the potential roles of ILCs in depression. A better understanding of the biology of ILCs may lead to the development of new therapeutic strategies for the management of depression. |
first_indexed | 2024-04-11T06:24:21Z |
format | Article |
id | doaj.art-9cb9d85ce7804e0da69523c94fcac822 |
institution | Directory Open Access Journal |
issn | 2666-1446 |
language | English |
last_indexed | 2024-04-11T06:24:21Z |
publishDate | 2022-12-01 |
publisher | Elsevier |
record_format | Article |
series | Biomarkers in Neuropsychiatry |
spelling | doaj.art-9cb9d85ce7804e0da69523c94fcac8222022-12-22T04:40:27ZengElsevierBiomarkers in Neuropsychiatry2666-14462022-12-017100055Innate lymphoid cells in depression: Current status and perspectivesAmit Kumar Madeshiya0Anilkumar Pillai1Pathophysiology of Neuropsychiatric Disorders Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USAPathophysiology of Neuropsychiatric Disorders Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Research and Development, Charlie Norwood VA Medical Center, Augusta, GA, USA; Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, GA, USA; Corresponding author at: Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.The recent discovery of innate lymphoid cells (ILCs) has provided new insights into our understanding of the pathogenesis of many disease conditions with immune dysregulation. Type 1 innate lymphoid cells (ILC1s) induce type I immunity and are characterized by the expression of signature cytokine IFN-γ and the master transcription factor T-bet; ILC2s stimulate type II immune responses and are defined by the expression of signature cytokines IL-5 and IL-13, and transcription factors ROR-α and GATA3; ILC3s requires the transcription factor RORγt and produce IL-22 and IL-17. ILCs are largely tissue-resident and are enriched at barrier surfaces of the mammalian body. Increasing evidence shows that inflammation is involved in the pathogenesis of depression. Although few studies have directly investigated the role of ILCs in depression, several studies have examined the levels of cytokines produced by ILCs in depressed subjects. This review summarizes the potential roles of ILCs in depression. A better understanding of the biology of ILCs may lead to the development of new therapeutic strategies for the management of depression.http://www.sciencedirect.com/science/article/pii/S2666144622000107Innate lymphoid cellsDepressionInflammation |
spellingShingle | Amit Kumar Madeshiya Anilkumar Pillai Innate lymphoid cells in depression: Current status and perspectives Biomarkers in Neuropsychiatry Innate lymphoid cells Depression Inflammation |
title | Innate lymphoid cells in depression: Current status and perspectives |
title_full | Innate lymphoid cells in depression: Current status and perspectives |
title_fullStr | Innate lymphoid cells in depression: Current status and perspectives |
title_full_unstemmed | Innate lymphoid cells in depression: Current status and perspectives |
title_short | Innate lymphoid cells in depression: Current status and perspectives |
title_sort | innate lymphoid cells in depression current status and perspectives |
topic | Innate lymphoid cells Depression Inflammation |
url | http://www.sciencedirect.com/science/article/pii/S2666144622000107 |
work_keys_str_mv | AT amitkumarmadeshiya innatelymphoidcellsindepressioncurrentstatusandperspectives AT anilkumarpillai innatelymphoidcellsindepressioncurrentstatusandperspectives |