Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon
Abstract The treatment of ulcerative colitis (UC) is still an intractable medical problem. Polysaccharides are promising candidates for the treatment of UC and have received widespread attention in recent years. The objective of this study was to explore the protective effect and underlying mechanis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Food Science & Nutrition |
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| Online Access: | https://doi.org/10.1002/fsn3.3653 |
| _version_ | 1797633816906432512 |
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| author | Shuo Wang Ping Wu Zongqiang Fan Xingrui He Jinqian Liu Ming Li Fang Chen |
| author_facet | Shuo Wang Ping Wu Zongqiang Fan Xingrui He Jinqian Liu Ming Li Fang Chen |
| author_sort | Shuo Wang |
| collection | DOAJ |
| description | Abstract The treatment of ulcerative colitis (UC) is still an intractable medical problem. Polysaccharides are promising candidates for the treatment of UC and have received widespread attention in recent years. The objective of this study was to explore the protective effect and underlying mechanism of dandelion polysaccharide (DP) on dextran sulfate sodium (DSS)‐induced colitis in mice. Our results showed that oral administration of DP could dramatically alleviate colonic lesions, as evidenced by reduced DAI scores, shortening of colon length, and ameliorating pathologic abnormalities in colons. Additionally, the expressions of pro‐inflammatory factors (TNF‐α, IL‐1β, and IL‐6) and the infiltration of inflammation‐regulation cells, marked by myeloperoxidase and F4/80, were also inhibited after DP treatment. Moreover, DP treatment also markedly suppressed the nuclear translocation of NF‐κB‐p65 and the activation of the NLRP3 inflammasome. Furthermore, DP also activated the Nrf2/HO‐1 pathway and reduced the oxidative stress induced by DSS. Overall, these results suggest that DP could be a promising novel therapeutic approach for the treatment of UC. |
| first_indexed | 2024-03-11T11:58:55Z |
| format | Article |
| id | doaj.art-9cba8d462ffc444a800571bdbceeda8b |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-03-11T11:58:55Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-9cba8d462ffc444a800571bdbceeda8b2023-11-08T09:39:18ZengWileyFood Science & Nutrition2048-71772023-11-0111117271728210.1002/fsn3.3653Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colonShuo Wang0Ping Wu1Zongqiang Fan2Xingrui He3Jinqian Liu4Ming Li5Fang Chen6School of Pharmaceutical Sciences Liaocheng University Liaocheng Shandong ChinaSchool of Pharmaceutical Sciences Liaocheng University Liaocheng Shandong ChinaSchool of Pharmaceutical Sciences Liaocheng University Liaocheng Shandong ChinaSchool of Pharmacy Hangzhou Normal University Hangzhou Zhejiang ChinaSchool of Pharmaceutical Sciences Liaocheng University Liaocheng Shandong ChinaShandong Academy of Occupational Health and Occupational Medicine Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong ChinaSchool of Pharmaceutical Sciences Liaocheng University Liaocheng Shandong ChinaAbstract The treatment of ulcerative colitis (UC) is still an intractable medical problem. Polysaccharides are promising candidates for the treatment of UC and have received widespread attention in recent years. The objective of this study was to explore the protective effect and underlying mechanism of dandelion polysaccharide (DP) on dextran sulfate sodium (DSS)‐induced colitis in mice. Our results showed that oral administration of DP could dramatically alleviate colonic lesions, as evidenced by reduced DAI scores, shortening of colon length, and ameliorating pathologic abnormalities in colons. Additionally, the expressions of pro‐inflammatory factors (TNF‐α, IL‐1β, and IL‐6) and the infiltration of inflammation‐regulation cells, marked by myeloperoxidase and F4/80, were also inhibited after DP treatment. Moreover, DP treatment also markedly suppressed the nuclear translocation of NF‐κB‐p65 and the activation of the NLRP3 inflammasome. Furthermore, DP also activated the Nrf2/HO‐1 pathway and reduced the oxidative stress induced by DSS. Overall, these results suggest that DP could be a promising novel therapeutic approach for the treatment of UC.https://doi.org/10.1002/fsn3.3653dandelion polysaccharideNF‐κBNLRP3Nrf2/HO‐1 pathwayulcerative colitis |
| spellingShingle | Shuo Wang Ping Wu Zongqiang Fan Xingrui He Jinqian Liu Ming Li Fang Chen Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon Food Science & Nutrition dandelion polysaccharide NF‐κB NLRP3 Nrf2/HO‐1 pathway ulcerative colitis |
| title | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
| title_full | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
| title_fullStr | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
| title_full_unstemmed | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
| title_short | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
| title_sort | dandelion polysaccharide treatment protects against dextran sodium sulfate induced colitis by suppressing nf κb nlrp3 inflammasome mediated inflammation and activating nrf2 in mouse colon |
| topic | dandelion polysaccharide NF‐κB NLRP3 Nrf2/HO‐1 pathway ulcerative colitis |
| url | https://doi.org/10.1002/fsn3.3653 |
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