An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites
An electroanalytical electrode for the detection of albendazole (ABZ) active ingredient in pharmaceutical dosage form and in contaminated animal-derived products was developed using a glassy carbon electrode modified with platinum-palladium nanoparticles. The electro-catalytic performance of the bim...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/11/1026 |
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| author | Ghadeer A. R. Y. Suaifan Mohammad F. Khanfar Mayadah B. Shehadeh Asmaa Alnajajrah Raghad Abuhamdan Sameer Ahmad Hasan |
| author_facet | Ghadeer A. R. Y. Suaifan Mohammad F. Khanfar Mayadah B. Shehadeh Asmaa Alnajajrah Raghad Abuhamdan Sameer Ahmad Hasan |
| author_sort | Ghadeer A. R. Y. Suaifan |
| collection | DOAJ |
| description | An electroanalytical electrode for the detection of albendazole (ABZ) active ingredient in pharmaceutical dosage form and in contaminated animal-derived products was developed using a glassy carbon electrode modified with platinum-palladium nanoparticles. The electro-catalytic performance of the bimetallic-modified glassy carbon electrode was compared with its bare counterpart. Under optimized conditions, the modified electrode revealed two well-resolved anodic peak currents at 1.10 and 1.23 V using differential pulse voltammetry. Pure ABZ, as well as ABZ in spiked foods (milk and chicken), were detected with little interference from the food matrix. This electrode demonstrated high sensitivity and applicability, with a lower limit of detection of 0.08 µmol L<sup>−1</sup> in aqueous solution and 10 µmol L<sup>−1</sup> in the contaminated ground chicken and 100 µmol L<sup>−1</sup> in the contaminated milk sample. The fabricated sensor is low in cost and appropriate for the estimation of albendazole in tablet dosage forms and biological samples, and so can act as a quality control tool in the pharmaceutical and food industry. |
| first_indexed | 2024-03-09T18:27:36Z |
| format | Article |
| id | doaj.art-9cbbdce4fd3b4f63a826acdc42e1926d |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T18:27:36Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-9cbbdce4fd3b4f63a826acdc42e1926d2023-11-24T07:48:43ZengMDPI AGBiosensors2079-63742022-11-011211102610.3390/bios12111026An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium NanocompositesGhadeer A. R. Y. Suaifan0Mohammad F. Khanfar1Mayadah B. Shehadeh2Asmaa Alnajajrah3Raghad Abuhamdan4Sameer Ahmad Hasan5Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanPharmaceutical-Chemical Engineering Department, School of Applied Medical Sciences, German Jordanian University, P.O. Box 35247, Amman 11180, JordanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanDepartment of Chemistry, The University of Jordan, Amman 11942, JordanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanBiomedical Engineering Department, School of Applied Medical Sciences, German Jordanian University, P.O. Box 35247, Amman 11180, JordanAn electroanalytical electrode for the detection of albendazole (ABZ) active ingredient in pharmaceutical dosage form and in contaminated animal-derived products was developed using a glassy carbon electrode modified with platinum-palladium nanoparticles. The electro-catalytic performance of the bimetallic-modified glassy carbon electrode was compared with its bare counterpart. Under optimized conditions, the modified electrode revealed two well-resolved anodic peak currents at 1.10 and 1.23 V using differential pulse voltammetry. Pure ABZ, as well as ABZ in spiked foods (milk and chicken), were detected with little interference from the food matrix. This electrode demonstrated high sensitivity and applicability, with a lower limit of detection of 0.08 µmol L<sup>−1</sup> in aqueous solution and 10 µmol L<sup>−1</sup> in the contaminated ground chicken and 100 µmol L<sup>−1</sup> in the contaminated milk sample. The fabricated sensor is low in cost and appropriate for the estimation of albendazole in tablet dosage forms and biological samples, and so can act as a quality control tool in the pharmaceutical and food industry.https://www.mdpi.com/2079-6374/12/11/1026albendazolecyclic voltammetrydifferential pulse voltammetrybinary catalystelectrode modification |
| spellingShingle | Ghadeer A. R. Y. Suaifan Mohammad F. Khanfar Mayadah B. Shehadeh Asmaa Alnajajrah Raghad Abuhamdan Sameer Ahmad Hasan An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites Biosensors albendazole cyclic voltammetry differential pulse voltammetry binary catalyst electrode modification |
| title | An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites |
| title_full | An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites |
| title_fullStr | An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites |
| title_full_unstemmed | An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites |
| title_short | An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites |
| title_sort | electrochemical sensor for the detection of albendazole using glassy carbon electrode modified with platinum palladium nanocomposites |
| topic | albendazole cyclic voltammetry differential pulse voltammetry binary catalyst electrode modification |
| url | https://www.mdpi.com/2079-6374/12/11/1026 |
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