WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS
ABSTRACT BACKGROUND: The infection for the hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality through its evolution to liver cirrhosis, end-stage liver complications and hepatocellular carcinoma. Currently, the new drugs for the HCV infection, based on direct antiv...
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
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| Series: | Arquivos de Gastroenterologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018002400343&lng=en&tlng=en |
| _version_ | 1819047316311506944 |
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| author | Giovanni Faria SILVA Vanessa Gutierrez de ANDRADE Alecsandro MOREIRA |
| author_facet | Giovanni Faria SILVA Vanessa Gutierrez de ANDRADE Alecsandro MOREIRA |
| author_sort | Giovanni Faria SILVA |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: The infection for the hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality through its evolution to liver cirrhosis, end-stage liver complications and hepatocellular carcinoma. Currently, the new drugs for the HCV infection, based on direct antiviral agents, have changed the outcomes in this setting. OBJECTIVE: To assess death incidence, during the wait for the treatment with the new drugs, and to analyze which independent variable (age, sex, ascite, HDA, albumin, α-fetoprotein, platelets and Meld score) had relation with death. METHODS: Prospective study with cirrhotic patients by HCV. Inclusion: cirrhotic patients by hepatic biopsy (METAVIR), clinic or image, detectable RNA (HCV). Exclusion: Other stages of hepatic fibrosis and hepatocellular carcinoma. Descriptive statistic in continue variables. Fisher Exact and Kaplan Meier and Cox Regression Analysis to assess the association of variables studied with death. P<0.05. RESULTS: A total of 129 patients were included. Of this, 73% were men. Mean age was 57.8±12.1, albumin of 3.5±0.6 mg/dL, platelets of 123.4±59.6 and Meld score of 10.59±3.56. The time of observation was 11.2±3.26 months, and the number of death 9/129 (6,9%). The Kaplan-Meier showed association between death with albumin lower than 2.9 (0.0006), MELD score higher than 15 (0.007) and α-fetoprotein higher than 40 ng/mL (<0.0001). Adjusted Cox Regression Analysis showed that α-fetoprotein higher than 40 ng/ml could be considered an independent risk for death. CONCLUSION: We conclude that, patients with advanced cirrhosis should be prioritized for treatment with direct antiviral agents. |
| first_indexed | 2024-12-21T10:58:25Z |
| format | Article |
| id | doaj.art-9cbbfe311d6147ef9d47707666641d55 |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-12-21T10:58:25Z |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-9cbbfe311d6147ef9d47707666641d552022-12-21T19:06:26ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-421955434334510.1590/s0004-2803.201800000-76S0004-28032018002400343WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTSGiovanni Faria SILVAVanessa Gutierrez de ANDRADEAlecsandro MOREIRAABSTRACT BACKGROUND: The infection for the hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality through its evolution to liver cirrhosis, end-stage liver complications and hepatocellular carcinoma. Currently, the new drugs for the HCV infection, based on direct antiviral agents, have changed the outcomes in this setting. OBJECTIVE: To assess death incidence, during the wait for the treatment with the new drugs, and to analyze which independent variable (age, sex, ascite, HDA, albumin, α-fetoprotein, platelets and Meld score) had relation with death. METHODS: Prospective study with cirrhotic patients by HCV. Inclusion: cirrhotic patients by hepatic biopsy (METAVIR), clinic or image, detectable RNA (HCV). Exclusion: Other stages of hepatic fibrosis and hepatocellular carcinoma. Descriptive statistic in continue variables. Fisher Exact and Kaplan Meier and Cox Regression Analysis to assess the association of variables studied with death. P<0.05. RESULTS: A total of 129 patients were included. Of this, 73% were men. Mean age was 57.8±12.1, albumin of 3.5±0.6 mg/dL, platelets of 123.4±59.6 and Meld score of 10.59±3.56. The time of observation was 11.2±3.26 months, and the number of death 9/129 (6,9%). The Kaplan-Meier showed association between death with albumin lower than 2.9 (0.0006), MELD score higher than 15 (0.007) and α-fetoprotein higher than 40 ng/mL (<0.0001). Adjusted Cox Regression Analysis showed that α-fetoprotein higher than 40 ng/ml could be considered an independent risk for death. CONCLUSION: We conclude that, patients with advanced cirrhosis should be prioritized for treatment with direct antiviral agents.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018002400343&lng=en&tlng=enHepacivirusCirrose hepática, tratamento farmacológicoLiver cirrhosis, mortalidade |
| spellingShingle | Giovanni Faria SILVA Vanessa Gutierrez de ANDRADE Alecsandro MOREIRA WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS Arquivos de Gastroenterologia Hepacivirus Cirrose hepática, tratamento farmacológico Liver cirrhosis, mortalidade |
| title | WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS |
| title_full | WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS |
| title_fullStr | WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS |
| title_full_unstemmed | WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS |
| title_short | WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS |
| title_sort | waiting daas list mortality impact in hcv cirrhotic patients |
| topic | Hepacivirus Cirrose hepática, tratamento farmacológico Liver cirrhosis, mortalidade |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018002400343&lng=en&tlng=en |
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