Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female Osteoporosis
Background: The aim of this study is to search for the predictive value of 3D fat analysis and calculation technique (FACT) and intravoxel incoherent motion (IVIM) parameters in identifying osteoporosis in women. Methods: We enrolled 48 female subjects who underwent 3.0 T MRI, including 3D FACT and...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/6/710 |
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| author | Shuo Zhang Qianrui Guo Yang Yang Hongbo Feng Yan Zhao Peng Guo Di Li Xuemei Du Qingwei Song |
| author_facet | Shuo Zhang Qianrui Guo Yang Yang Hongbo Feng Yan Zhao Peng Guo Di Li Xuemei Du Qingwei Song |
| author_sort | Shuo Zhang |
| collection | DOAJ |
| description | Background: The aim of this study is to search for the predictive value of 3D fat analysis and calculation technique (FACT) and intravoxel incoherent motion (IVIM) parameters in identifying osteoporosis in women. Methods: We enrolled 48 female subjects who underwent 3.0 T MRI, including 3D FACT and IVIM sequences. Bone mineral density (BMD) values and Fracture Risk Assessment (FRAX) scores were obtained. Proton density fat fraction (PDFF) in the bone marrow and the real diffusion (D) value of intervertebral discs were measured on 3D FACT and IVIM images, respectively. Accuracy and bias were assessed by linear regression analysis and Bland–Altman plots. Intraclass correlation coefficients were used to assess the measurements’ reproducibility. Spearman’s rank correlation was applied to explore the correlation. MRI-based parameters were tested for significant differences among the three groups using ANOVA analyses. A receiver operating characteristic (ROC) analysis was performed. Results: The PDFF of the vertebral body showed a negative correlation with BMD (R = −0.393, <i>p</i> = 0.005) and a positive correlation with the FRAX score (R = 0.706, <i>p</i> < 0.001). The D value of intervertebral discs showed a positive correlation with BMD (R = 0.321, <i>p</i> = 0.024) and a negative correlation with the FRAX score (R = −0.334, <i>p</i> = 0.019). The area under the curve values from the ROC analysis showed that the 3D FACT and IVIM sequences could accurately differentiate between normal and osteoporosis (AUC = 0.88 using the PDFF; AUC = 0.77 using the D value). The PDFF value demonstrated a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 78.6%, 89.5%, 84.6%, and 85.0%, respectively, in its ability to predict osteoporosis. The D value had a sensitivity, specificity, PPV, and NPV of 63.16%, 92.9%, 65.0%, and 77.8%, respectively, for predicting osteoporosis. Conclusions: The 3D FACT- and IVIM-measured PDFF and D values are promising biomarkers in the assessment of bone quality and fracture risk. |
| first_indexed | 2024-03-11T02:45:52Z |
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| language | English |
| last_indexed | 2024-03-11T02:45:52Z |
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| spelling | doaj.art-9cbce54b410b4ba1b9e4e602eb18d27e2023-11-18T09:21:41ZengMDPI AGBioengineering2306-53542023-06-0110671010.3390/bioengineering10060710Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female OsteoporosisShuo Zhang0Qianrui Guo1Yang Yang2Hongbo Feng3Yan Zhao4Peng Guo5Di Li6Xuemei Du7Qingwei Song8Department of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaBeijing United Imaging Research Institute of Intelligent Imaging, Beijing 100094, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Information Center, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaBackground: The aim of this study is to search for the predictive value of 3D fat analysis and calculation technique (FACT) and intravoxel incoherent motion (IVIM) parameters in identifying osteoporosis in women. Methods: We enrolled 48 female subjects who underwent 3.0 T MRI, including 3D FACT and IVIM sequences. Bone mineral density (BMD) values and Fracture Risk Assessment (FRAX) scores were obtained. Proton density fat fraction (PDFF) in the bone marrow and the real diffusion (D) value of intervertebral discs were measured on 3D FACT and IVIM images, respectively. Accuracy and bias were assessed by linear regression analysis and Bland–Altman plots. Intraclass correlation coefficients were used to assess the measurements’ reproducibility. Spearman’s rank correlation was applied to explore the correlation. MRI-based parameters were tested for significant differences among the three groups using ANOVA analyses. A receiver operating characteristic (ROC) analysis was performed. Results: The PDFF of the vertebral body showed a negative correlation with BMD (R = −0.393, <i>p</i> = 0.005) and a positive correlation with the FRAX score (R = 0.706, <i>p</i> < 0.001). The D value of intervertebral discs showed a positive correlation with BMD (R = 0.321, <i>p</i> = 0.024) and a negative correlation with the FRAX score (R = −0.334, <i>p</i> = 0.019). The area under the curve values from the ROC analysis showed that the 3D FACT and IVIM sequences could accurately differentiate between normal and osteoporosis (AUC = 0.88 using the PDFF; AUC = 0.77 using the D value). The PDFF value demonstrated a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 78.6%, 89.5%, 84.6%, and 85.0%, respectively, in its ability to predict osteoporosis. The D value had a sensitivity, specificity, PPV, and NPV of 63.16%, 92.9%, 65.0%, and 77.8%, respectively, for predicting osteoporosis. Conclusions: The 3D FACT- and IVIM-measured PDFF and D values are promising biomarkers in the assessment of bone quality and fracture risk.https://www.mdpi.com/2306-5354/10/6/710fat analysis and calculation techniqueintravoxel incoherent motionvertebral bodiesintervertebral discsbone mineral density |
| spellingShingle | Shuo Zhang Qianrui Guo Yang Yang Hongbo Feng Yan Zhao Peng Guo Di Li Xuemei Du Qingwei Song Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female Osteoporosis Bioengineering fat analysis and calculation technique intravoxel incoherent motion vertebral bodies intervertebral discs bone mineral density |
| title | Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female Osteoporosis |
| title_full | Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female Osteoporosis |
| title_fullStr | Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female Osteoporosis |
| title_full_unstemmed | Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female Osteoporosis |
| title_short | Feasibility Study of 3D FACT and IVIM Sequences in the Evaluation of Female Osteoporosis |
| title_sort | feasibility study of 3d fact and ivim sequences in the evaluation of female osteoporosis |
| topic | fat analysis and calculation technique intravoxel incoherent motion vertebral bodies intervertebral discs bone mineral density |
| url | https://www.mdpi.com/2306-5354/10/6/710 |
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