The Role of Hyaluronic Acid in Intervertebral Disc Regeneration
Intervertebral disc (IVD) degeneration is a leading cause of low back pain worldwide, incurring a significant burden on the healthcare system and society. IVD degeneration is characterized by an abnormal cell-mediated response leading to the stimulation of different catabolic biomarkers and activati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/18/6257 |
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| author | Zepur Kazezian Kieran Joyce Abhay Pandit |
| author_facet | Zepur Kazezian Kieran Joyce Abhay Pandit |
| author_sort | Zepur Kazezian |
| collection | DOAJ |
| description | Intervertebral disc (IVD) degeneration is a leading cause of low back pain worldwide, incurring a significant burden on the healthcare system and society. IVD degeneration is characterized by an abnormal cell-mediated response leading to the stimulation of different catabolic biomarkers and activation of signalling pathways. In the last few decades, hyaluronic acid (HA), which has been broadly used in tissue-engineering, has popularised due to its anti-inflammatory, analgesic and extracellular matrix enhancing properties. Hence, there is expressed interest in treating the IVD using different HA compositions. An ideal HA-based biomaterial needs to be compatible and supportive of the disc microenvironment in general and inhibit inflammation and downstream cascades leading to the innervation, vascularisation and pain sensation in particular. High molecular weight hyaluronic acid (HMW HA) and HA-based biomaterials used as therapeutic delivery platforms have been trialled in preclinical models and clinical trials. In this paper, we reviewed a series of studies focused on assessing the effect of different compositions of HA as a therapeutic, targeting IVD degeneration. Overall, tremendous advances have been made towards an optimal form of a HA biomaterial to target specific biomarkers associated with IVD degeneration, but further optimization is necessary to address regeneration. |
| first_indexed | 2024-03-10T16:27:38Z |
| format | Article |
| id | doaj.art-9cbf7ba79d7c4536839f818b20d933d6 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T16:27:38Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-9cbf7ba79d7c4536839f818b20d933d62023-11-20T13:04:14ZengMDPI AGApplied Sciences2076-34172020-09-011018625710.3390/app10186257The Role of Hyaluronic Acid in Intervertebral Disc RegenerationZepur Kazezian0Kieran Joyce1Abhay Pandit2CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, H91 W2TY Galway, IrelandCÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, H91 W2TY Galway, IrelandCÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, H91 W2TY Galway, IrelandIntervertebral disc (IVD) degeneration is a leading cause of low back pain worldwide, incurring a significant burden on the healthcare system and society. IVD degeneration is characterized by an abnormal cell-mediated response leading to the stimulation of different catabolic biomarkers and activation of signalling pathways. In the last few decades, hyaluronic acid (HA), which has been broadly used in tissue-engineering, has popularised due to its anti-inflammatory, analgesic and extracellular matrix enhancing properties. Hence, there is expressed interest in treating the IVD using different HA compositions. An ideal HA-based biomaterial needs to be compatible and supportive of the disc microenvironment in general and inhibit inflammation and downstream cascades leading to the innervation, vascularisation and pain sensation in particular. High molecular weight hyaluronic acid (HMW HA) and HA-based biomaterials used as therapeutic delivery platforms have been trialled in preclinical models and clinical trials. In this paper, we reviewed a series of studies focused on assessing the effect of different compositions of HA as a therapeutic, targeting IVD degeneration. Overall, tremendous advances have been made towards an optimal form of a HA biomaterial to target specific biomarkers associated with IVD degeneration, but further optimization is necessary to address regeneration.https://www.mdpi.com/2076-3417/10/18/6257hyaluronic aciddisc repairannulus fibrosus repairbiomaterialsinflammatory biomarkers and signalling pathways |
| spellingShingle | Zepur Kazezian Kieran Joyce Abhay Pandit The Role of Hyaluronic Acid in Intervertebral Disc Regeneration Applied Sciences hyaluronic acid disc repair annulus fibrosus repair biomaterials inflammatory biomarkers and signalling pathways |
| title | The Role of Hyaluronic Acid in Intervertebral Disc Regeneration |
| title_full | The Role of Hyaluronic Acid in Intervertebral Disc Regeneration |
| title_fullStr | The Role of Hyaluronic Acid in Intervertebral Disc Regeneration |
| title_full_unstemmed | The Role of Hyaluronic Acid in Intervertebral Disc Regeneration |
| title_short | The Role of Hyaluronic Acid in Intervertebral Disc Regeneration |
| title_sort | role of hyaluronic acid in intervertebral disc regeneration |
| topic | hyaluronic acid disc repair annulus fibrosus repair biomaterials inflammatory biomarkers and signalling pathways |
| url | https://www.mdpi.com/2076-3417/10/18/6257 |
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