Systems biology of microbial exopolysaccharides production
Exopolysaccharides (EPS) produced by diverse group of microbial systems are rapidly emerging as new and industrially important biomaterials. Due to their unique and complex chemical structures and many interesting physicochemical and rheological properties with novel functionality, the microbial EPS...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-12-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00200/full |
| _version_ | 1818766057384443904 |
|---|---|
| author | Ozlem eAtes |
| author_facet | Ozlem eAtes |
| author_sort | Ozlem eAtes |
| collection | DOAJ |
| description | Exopolysaccharides (EPS) produced by diverse group of microbial systems are rapidly emerging as new and industrially important biomaterials. Due to their unique and complex chemical structures and many interesting physicochemical and rheological properties with novel functionality, the microbial EPSs find wide range of commercial applications in various fields of the economy such as food, feed, packaging, chemical, textile, cosmetics and pharmaceutical industry, agriculture and medicine. EPSs are mainly associated with high-value applications and they have received considerable research attention over recent decades with their biocompatibility, biodegradability, and both environmental and human compatibility. However only a few microbial EPSs have achieved to be used commercially due to their high production costs. The emerging need to overcome economic hurdles and the increasing significance of microbial EPSs in industrial and medical biotechnology call for the elucidation of the interrelations between metabolic pathways and EPS biosynthesis mechanism in order to control and hence enhance its microbial productivity. Moreover a better understanding of biosynthesis mechanism is a significant issue for improvement of product quality and properties and also for the design of novel strains. Therefore a systems-based approach constitutes an important step towards understanding the interplay between metabolism and EPS biosynthesis and further enhances its metabolic performance for industrial application. In this review, primarily the microbial EPSs, their biosynthesis mechanism and important factors for their production will be discussed. After this brief introduction, recent literature on the application of omics technologies and systems biology tools for the improvement of production yields will be critically evaluated. Special focus will be given to EPSs with high market value such as xanthan, levan, pullulan and dextran. |
| first_indexed | 2024-12-18T08:27:56Z |
| format | Article |
| id | doaj.art-9cc21a1d8aa74f7fb4f315fa58dac42c |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-18T08:27:56Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-9cc21a1d8aa74f7fb4f315fa58dac42c2022-12-21T21:14:33ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852015-12-01310.3389/fbioe.2015.00200162636Systems biology of microbial exopolysaccharides productionOzlem eAtes0Nisantasi UniversityExopolysaccharides (EPS) produced by diverse group of microbial systems are rapidly emerging as new and industrially important biomaterials. Due to their unique and complex chemical structures and many interesting physicochemical and rheological properties with novel functionality, the microbial EPSs find wide range of commercial applications in various fields of the economy such as food, feed, packaging, chemical, textile, cosmetics and pharmaceutical industry, agriculture and medicine. EPSs are mainly associated with high-value applications and they have received considerable research attention over recent decades with their biocompatibility, biodegradability, and both environmental and human compatibility. However only a few microbial EPSs have achieved to be used commercially due to their high production costs. The emerging need to overcome economic hurdles and the increasing significance of microbial EPSs in industrial and medical biotechnology call for the elucidation of the interrelations between metabolic pathways and EPS biosynthesis mechanism in order to control and hence enhance its microbial productivity. Moreover a better understanding of biosynthesis mechanism is a significant issue for improvement of product quality and properties and also for the design of novel strains. Therefore a systems-based approach constitutes an important step towards understanding the interplay between metabolism and EPS biosynthesis and further enhances its metabolic performance for industrial application. In this review, primarily the microbial EPSs, their biosynthesis mechanism and important factors for their production will be discussed. After this brief introduction, recent literature on the application of omics technologies and systems biology tools for the improvement of production yields will be critically evaluated. Special focus will be given to EPSs with high market value such as xanthan, levan, pullulan and dextran.http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00200/fullSystems BiologyexopolysaccharidesPullulanEPSXanthanDextran |
| spellingShingle | Ozlem eAtes Systems biology of microbial exopolysaccharides production Frontiers in Bioengineering and Biotechnology Systems Biology exopolysaccharides Pullulan EPS Xanthan Dextran |
| title | Systems biology of microbial exopolysaccharides production |
| title_full | Systems biology of microbial exopolysaccharides production |
| title_fullStr | Systems biology of microbial exopolysaccharides production |
| title_full_unstemmed | Systems biology of microbial exopolysaccharides production |
| title_short | Systems biology of microbial exopolysaccharides production |
| title_sort | systems biology of microbial exopolysaccharides production |
| topic | Systems Biology exopolysaccharides Pullulan EPS Xanthan Dextran |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00200/full |
| work_keys_str_mv | AT ozlemeates systemsbiologyofmicrobialexopolysaccharidesproduction |