TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs

TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs

Abstract The pregnane X receptor (PXR) is an important regulator of hepatocellular carcinoma cellular resistance to antitumor drugs. Activation of PXR was modulated by the co-regulators. The target protein for the Xenopus plus end-directed kinesin-like protein (Xklp2) known as TPX2 that was previous...

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Main Authors: Hongbo Wang, Fang Chu, Xiao-feng Zhang, Peng Zhang, Li-xin Li, Yun-long Zhuang, Xiao-feng Niu, Xi He, Zhi-jie Li, Ying Bai, Da Mao, Zhen-wen Liu, Da-li Zhang, Bo-an Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05537-7

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