Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours
Chemotherapy is still the first line of treatment for most cancer patients. Patients receiving chemotherapy are generally prone to infections, which result in complications, such as sepsis, mucositis, colitis, and diarrhoea. Several nutritional approaches have been trialled to counter the chemothera...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/7/1759 |
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| author | Neeraj K. Singh Jeffrey M. Beckett Krishnakumar Kalpurath Muhammad Ishaq Tauseef Ahmad Rajaraman D. Eri |
| author_facet | Neeraj K. Singh Jeffrey M. Beckett Krishnakumar Kalpurath Muhammad Ishaq Tauseef Ahmad Rajaraman D. Eri |
| author_sort | Neeraj K. Singh |
| collection | DOAJ |
| description | Chemotherapy is still the first line of treatment for most cancer patients. Patients receiving chemotherapy are generally prone to infections, which result in complications, such as sepsis, mucositis, colitis, and diarrhoea. Several nutritional approaches have been trialled to counter the chemotherapy-associated side effects in cancer patients, but none have yet been approved for routine clinical use. One of the approaches to reduce or avoid chemotherapy-associated complications is to restore the gut microbiota. Gut microbiota is essential for the healthy functioning of the immune system, metabolism, and the regulation of other molecular responses in the body. Chemotherapy erodes the mucosal layer of the gastrointestinal tract and results in the loss of gut microbiota. One of the ways to restore the gut microbiota is through the use of probiotics. Probiotics are the ‘good’ bacteria that may provide health benefits if consumed in appropriate amounts. Some studies have highlighted that the consumption of probiotics in combination with prebiotics, known as synbiotics, may provide better health benefits when compared to probiotics alone. This review discusses the different nutritional approaches that have been studied in an attempt to combat chemotherapy-associated side effects in cancer patients with a particular focus on the use of pre-, pro- and synbiotics. |
| first_indexed | 2024-03-11T05:27:59Z |
| format | Article |
| id | doaj.art-9cc4a49bb5404dddbaf531753645cdc1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T05:27:59Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9cc4a49bb5404dddbaf531753645cdc12023-11-17T17:21:39ZengMDPI AGNutrients2072-66432023-04-01157175910.3390/nu15071759Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid TumoursNeeraj K. Singh0Jeffrey M. Beckett1Krishnakumar Kalpurath2Muhammad Ishaq3Tauseef Ahmad4Rajaraman D. Eri5School of Health Sciences, University of Tasmania, Newnham, Launceston 7248, AustraliaSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, AustraliaSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, AustraliaSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, AustraliaSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, AustraliaSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, AustraliaChemotherapy is still the first line of treatment for most cancer patients. Patients receiving chemotherapy are generally prone to infections, which result in complications, such as sepsis, mucositis, colitis, and diarrhoea. Several nutritional approaches have been trialled to counter the chemotherapy-associated side effects in cancer patients, but none have yet been approved for routine clinical use. One of the approaches to reduce or avoid chemotherapy-associated complications is to restore the gut microbiota. Gut microbiota is essential for the healthy functioning of the immune system, metabolism, and the regulation of other molecular responses in the body. Chemotherapy erodes the mucosal layer of the gastrointestinal tract and results in the loss of gut microbiota. One of the ways to restore the gut microbiota is through the use of probiotics. Probiotics are the ‘good’ bacteria that may provide health benefits if consumed in appropriate amounts. Some studies have highlighted that the consumption of probiotics in combination with prebiotics, known as synbiotics, may provide better health benefits when compared to probiotics alone. This review discusses the different nutritional approaches that have been studied in an attempt to combat chemotherapy-associated side effects in cancer patients with a particular focus on the use of pre-, pro- and synbiotics.https://www.mdpi.com/2072-6643/15/7/1759cancerchemotherapyprobioticsprebioticssynbiotics |
| spellingShingle | Neeraj K. Singh Jeffrey M. Beckett Krishnakumar Kalpurath Muhammad Ishaq Tauseef Ahmad Rajaraman D. Eri Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours Nutrients cancer chemotherapy probiotics prebiotics synbiotics |
| title | Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours |
| title_full | Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours |
| title_fullStr | Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours |
| title_full_unstemmed | Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours |
| title_short | Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours |
| title_sort | synbiotics as supplemental therapy for the alleviation of chemotherapy associated symptoms in patients with solid tumours |
| topic | cancer chemotherapy probiotics prebiotics synbiotics |
| url | https://www.mdpi.com/2072-6643/15/7/1759 |
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