Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control study
Background: Neonatal mortality rate (NMR) refers to the number of deaths occurring from birth to 28 days of life per-1000 Live Births (LB). The global NMR declined from 37 deaths per- 1,000 LB in 1990 to 18 in 2017, whereas it was 27 deaths per 1000 LB in the Sub-Saharan region. Ethiopia plans to re...
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Elsevier
2022-09-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022016772 |
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| author | Bedru Jemal Teshome Abebe Abebayehu Zemedkun Bivash Basu Simeneh Mola Derartu Neme Seyoum Hailu |
| author_facet | Bedru Jemal Teshome Abebe Abebayehu Zemedkun Bivash Basu Simeneh Mola Derartu Neme Seyoum Hailu |
| author_sort | Bedru Jemal |
| collection | DOAJ |
| description | Background: Neonatal mortality rate (NMR) refers to the number of deaths occurring from birth to 28 days of life per-1000 Live Births (LB). The global NMR declined from 37 deaths per- 1,000 LB in 1990 to 18 in 2017, whereas it was 27 deaths per 1000 LB in the Sub-Saharan region. Ethiopia plans to reduce the NMR from 28 deaths to 11 deaths per 1,000 LB by 2020 and to end all preventable child deaths by 2035. The aim of this study was to identify the determinants of neonatal mortality in the neonatal intensive care unit (NICU) of Dilla University Referral Hospital (DURH). Methods: An age-matched case control study was conducted at DURH's NICU. Two controls having age 2 days before or after the case were used for matching. One hundred eighteen cases (died) and 236 controls (survived) neonates admitted to the NICU from January 11, 2018, to February 25, 2020, were studied. Missed data were filled by multiple imputations. Multicollinearity was checked by the variance inflation factor. For variables with a P-value <0.2 on bivariable conditional logistic regression, multivariable conditional logistic regression analysis was performed to control for confounders using clogit command in a survival package to identify the risk factors for neonatal mortality using R version 3.6.3. Result: Gestational age <37 weeks (Adjusted matched odds ratio (AmOR): 14.02; 95% confidence interval (CI): 3.68–53.46), first-minute APGAR score <7 (AmOR: 5.68; 95% CI: 1.76–18.31), perinatal asphyxia (PNA) (AmOR: 4.62; 95% CI: 1.15–18.53) and being twins (AmOR: 6.84; 95% CI: 1.34–34.96) were significantly associated with neonatal deaths in our study. Furthermore, antenatal care and follow-up during pregnancy (AmOR: 0.15; 95% CI: 0.04–0.53) and having a normal random blood sugar level at admission (AmOR: 0.1; 95% CI: (0.02–0.66) were found to be determinant of neonatal mortalities in our study. Conclusion: Gestational age less than 37 weeks, first-minute APGAR scores <7, being twins, diagnosis of PNA, antenatal care and follow-up of mothers during pregnancy and normoglycemia in neonates at admission were significant determinant of neonatal death in the NICU of DURH. |
| first_indexed | 2024-04-11T09:10:34Z |
| format | Article |
| id | doaj.art-9cc4ebecbc1b475da632632828c5ace5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T09:10:34Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
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| spelling | doaj.art-9cc4ebecbc1b475da632632828c5ace52022-12-22T04:32:31ZengElsevierHeliyon2405-84402022-09-0189e10389Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control studyBedru Jemal0Teshome Abebe1Abebayehu Zemedkun2Bivash Basu3Simeneh Mola4Derartu Neme5Seyoum Hailu6Department of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia; Corresponding author.Department of Anesthesiology, College of Medicine and Health Sciences, Diredawa University, Diredawa, EthiopiaDepartment of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Dilla, EthiopiaDepartment of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Dilla, EthiopiaDepartment of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Dilla, EthiopiaDepartment of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Dilla, EthiopiaDepartment of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Dilla, EthiopiaBackground: Neonatal mortality rate (NMR) refers to the number of deaths occurring from birth to 28 days of life per-1000 Live Births (LB). The global NMR declined from 37 deaths per- 1,000 LB in 1990 to 18 in 2017, whereas it was 27 deaths per 1000 LB in the Sub-Saharan region. Ethiopia plans to reduce the NMR from 28 deaths to 11 deaths per 1,000 LB by 2020 and to end all preventable child deaths by 2035. The aim of this study was to identify the determinants of neonatal mortality in the neonatal intensive care unit (NICU) of Dilla University Referral Hospital (DURH). Methods: An age-matched case control study was conducted at DURH's NICU. Two controls having age 2 days before or after the case were used for matching. One hundred eighteen cases (died) and 236 controls (survived) neonates admitted to the NICU from January 11, 2018, to February 25, 2020, were studied. Missed data were filled by multiple imputations. Multicollinearity was checked by the variance inflation factor. For variables with a P-value <0.2 on bivariable conditional logistic regression, multivariable conditional logistic regression analysis was performed to control for confounders using clogit command in a survival package to identify the risk factors for neonatal mortality using R version 3.6.3. Result: Gestational age <37 weeks (Adjusted matched odds ratio (AmOR): 14.02; 95% confidence interval (CI): 3.68–53.46), first-minute APGAR score <7 (AmOR: 5.68; 95% CI: 1.76–18.31), perinatal asphyxia (PNA) (AmOR: 4.62; 95% CI: 1.15–18.53) and being twins (AmOR: 6.84; 95% CI: 1.34–34.96) were significantly associated with neonatal deaths in our study. Furthermore, antenatal care and follow-up during pregnancy (AmOR: 0.15; 95% CI: 0.04–0.53) and having a normal random blood sugar level at admission (AmOR: 0.1; 95% CI: (0.02–0.66) were found to be determinant of neonatal mortalities in our study. Conclusion: Gestational age less than 37 weeks, first-minute APGAR scores <7, being twins, diagnosis of PNA, antenatal care and follow-up of mothers during pregnancy and normoglycemia in neonates at admission were significant determinant of neonatal death in the NICU of DURH.http://www.sciencedirect.com/science/article/pii/S2405844022016772Neonatal mortalityNICUCase controlPredictor |
| spellingShingle | Bedru Jemal Teshome Abebe Abebayehu Zemedkun Bivash Basu Simeneh Mola Derartu Neme Seyoum Hailu Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control study Heliyon Neonatal mortality NICU Case control Predictor |
| title | Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control study |
| title_full | Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control study |
| title_fullStr | Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control study |
| title_full_unstemmed | Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control study |
| title_short | Determinants of neonatal mortality in the neonatal intensive care unit of Dilla University Referral Hospital, Southern Ethiopia; 2019–2020; A matched, case–control study |
| title_sort | determinants of neonatal mortality in the neonatal intensive care unit of dilla university referral hospital southern ethiopia 2019 2020 a matched case control study |
| topic | Neonatal mortality NICU Case control Predictor |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022016772 |
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