Unveiling the immunomodulatory shift: Epithelial-mesenchymal transition Alters immune mechanisms of amniotic epithelial cells

Unveiling the immunomodulatory shift: Epithelial-mesenchymal transition Alters immune mechanisms of amniotic epithelial cells

Summary: Epithelial-mesenchymal transition (EMT) changes cell phenotype by affecting immune properties of amniotic epithelial cells (AECs). The present study shows how the response to lipopolysaccharide of cells collected pre- (eAECs) and post-EMT (mAECs) induces changes in their transcriptomics pro...

Full description

Bibliographic Details
Main Authors:	Valeria Di Lollo, Angelo Canciello, Alessia Peserico, Massimiliano Orsini, Valentina Russo, Adrián Cerveró-Varona, Beatrice Dufrusine, Mohammad El Khatib, Valentina Curini, Annunziata Mauro, Paolo Berardinelli, Cathy Tournier, Massimo Ancora, Cesare Cammà, Enrico Dainese, Luana Fiorella Mincarelli, Barbara Barboni
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Series:	iScience
Subjects:	Immunology Cell biology Stem cells research Transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223016590

Similar Items

Tendon Healing Response Is Dependent on Epithelial–Mesenchymal–Tendon Transition State of Amniotic Epithelial Stem Cells
by: Valentina Russo, et al.
Published: (2022-05-01)

Graphene oxide accelerates TGFβ-mediated epithelial-mesenchymal transition and stimulates pro-inflammatory immune response in amniotic epithelial cells
by: Adrian Cerverò-Varona, et al.
Published: (2023-10-01)

Tendon 3D Scaffolds Establish a Tailored Microenvironment Instructing Paracrine Mediated Regenerative Amniotic Epithelial Stem Cells Potential
by: Valentina Russo, et al.
Published: (2022-10-01)

Tendon Biomimetic Electrospun PLGA Fleeces Induce an Early Epithelial-Mesenchymal Transition and Tenogenic Differentiation on Amniotic Epithelial Stem Cells
by: Valentina Russo, et al.
Published: (2020-01-01)

Electrospun PLGA Fiber Diameter and Alignment of Tendon Biomimetic Fleece Potentiate Tenogenic Differentiation and Immunomodulatory Function of Amniotic Epithelial Stem Cells
by: Mohammad El Khatib, et al.
Published: (2020-05-01)

Hypoxia-Mimetic CoCl<sub>2</sub> Agent Enhances Pro-Angiogenic Activities in Ovine Amniotic Epithelial Cells-Derived Conditioned Medium
by: Miriam Di Mattia, et al.
Published: (2022-01-01)

Indirect co-culture with tendons or tenocytes can program amniotic epithelial cells towards stepwise tenogenic differentiation.
by: Barbara Barboni, et al.
Published: (2012-01-01)

“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
by: Angelo Canciello, et al.
Published: (2022-11-01)

Fabrication and Plasma Surface Activation of Aligned Electrospun PLGA Fiber Fleeces with Improved Adhesion and Infiltration of Amniotic Epithelial Stem Cells Maintaining their Teno-inductive Potential
by: Mohammad El Khatib, et al.
Published: (2020-07-01)

Amniotic Epithelial Stem Cells Counteract Acidic Degradation By-Products of Electrospun PLGA Scaffold by Improving Their Immunomodulatory Profile In Vitro
by: Mohammad El Khatib, et al.
Published: (2021-11-01)

Assessing the functional potential of conditioned media derived from amniotic epithelial stem cells engineered on 3D biomimetic scaffolds: An in vitro model for tendon regeneration
by: Valentina Russo, et al.
Published: (2024-04-01)

Achilles Tendon Regeneration can be Improved by Amniotic Epithelial Cell Allotransplantation
by: B. Barboni, et al.
Published: (2012-11-01)

Progesterone Prolongs Viability and Anti-inflammatory Functions of Explanted Preterm Ovine Amniotic Membrane
by: Angelo Canciello, et al.
Published: (2020-03-01)

Amniotic epithelial cells: a new tool to combat aging and age-related diseases?
by: Clara Di Germanio, et al.
Published: (2016-11-01)

Placental amniotic epithelial cells and their therapeutic potential in liver diseases
by: Asli eTahan, et al.
Published: (2014-12-01)

Serum-Free Cryopreservation of Human Amniotic Epithelial Cells
by: Hasan Niknejad, et al.
Published: (2013-06-01)

In Vitro Differentiation of Human Amniotic Epithelial Cells into Hepatocyte-like Cells
by: Marcin Michalik, et al.
Published: (2022-07-01)

Insight into Hypoxia Stemness Control
by: Miriam Di Mattia, et al.
Published: (2021-08-01)

Nanotechnology-Assisted Cell Tracking
by: Alessia Peserico, et al.
Published: (2022-04-01)

Crossing of the epithelial barriers by Bacillus anthracis: the Known and the Unknown
by: Pierre L Goossens, et al.
Published: (2015-10-01)

Differentiation of human amniotic epithelial cells into corneal epithelial-like cells </b><i><b>in vitro</b>
by: Min Yao, et al.
Published: (2013-10-01)

Application of human amniotic epithelial cells in regenerative medicine: a systematic review
by: Qiuwan Zhang, et al.
Published: (2020-10-01)

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications
by: Chen Qiu, et al.
Published: (2020-10-01)

Repair of Retinal Degeneration by Human Amniotic Epithelial Stem Cell–Derived Photoreceptor–like Cells
by: Jinying Li, et al.
Published: (2022-08-01)

Human amniotic epithelial cells improve fertility in an intrauterine adhesion mouse model
by: Boning Li, et al.
Published: (2019-08-01)

The Bottlenecks in Translating Placenta-Derived Amniotic Epithelial and Mesenchymal Stromal Cells Into the Clinic: Current Discrepancies in Marker Reports
by: Seyyed-Hadi Ghamari, et al.
Published: (2020-03-01)

In Vivo Model of Osteoarthritis to Compare Allogenic Amniotic Epithelial Stem Cells and Autologous Adipose Derived Cells
by: Francesca Veronesi, et al.
Published: (2022-04-01)

Method and key points for isolation of human amniotic epithelial cells with high yield, viability and purity
by: Hossein Motedayyen, et al.
Published: (2017-11-01)

Human amniotic epithelial cells ameliorate kidney damage in ischemia-reperfusion mouse model of acute kidney injury
by: Yifei Ren, et al.
Published: (2020-09-01)

Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration
by: Jinying Li, et al.
Published: (2021-09-01)

Mammal comparative tendon biology: advances in regulatory mechanisms through a computational modeling
by: Alessia Peserico, et al.
Published: (2023-04-01)

The Effects of FGF8 and Shh on Expression of Dopaminergic Markers from Human Amniotic Epithelial Cells
by: Ahmadian A, et al.
Published: (2011-01-01)

In vitro tissue engineering of lamellar cornea using human amniotic epithelial cells and rabbit cornea stroma
by: Xiao-Yong Liu, et al.
Published: (2013-08-01)

The effect of lipopolysaccharide on the expression level of immunomodulatory and immunostimulatory factors of human amniotic epithelial cells
by: Ramezan Ali Taheri, et al.
Published: (2018-05-01)

Regulatory roles of Osteopontin in lung epithelial inflammation and epithelial‐telocyte interaction
by: Huirong Fu, et al.
Published: (2023-08-01)

Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure
by: Quan-Wen Liu, et al.
Published: (2018-11-01)

Transcriptomic and Functional Evidence Show Similarities between Human Amniotic Epithelial Stem Cells and Keratinocytes
by: Li-Ping Liu, et al.
Published: (2021-12-01)

The effect of human amniotic epithelial cell on dendritic cell differentiation of peripheral blood monocytes: An experimental study
by: Bahare Keshavarzi, et al.
Published: (2020-06-01)

The Synergistic Anti-Apoptosis Effects of Amniotic Epithelial Stem Cell Conditioned Medium and Ponesimod on the Oligodendrocyte Cells
by: Fahimeh Safaeinejad, et al.
Published: (2021-06-01)

Culture of epithelial cells /
by: Freshney, R. Ian, et al.
Published: (2002)