Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

Abstract Purpose/objective Radiotherapy (RT) induces an immunogenic antitumor response, but also some immunosuppressive barriers. It remains unclear how different fractionation protocols can modulate the immune microenvironment. Clinical studies are ongoing to evaluate immune checkpoint inhibitors (...

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Bibliographic Details
Main Authors: Mathieu Grapin, Corentin Richard, Emeric Limagne, Romain Boidot, Véronique Morgand, Aurélie Bertaut, Valentin Derangere, Pierre-Antoine Laurent, Marion Thibaudin, Jean David Fumet, Gilles Crehange, François Ghiringhelli, Céline Mirjolet
Format: Article
Language:English
Published: BMJ Publishing Group 2019-06-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Radiotherapy fractionation
Immunotherapy
Immune response
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s40425-019-0634-9

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