Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese
Background Associations of neutrophil-to-lymphocyte ratio (NLR) and its longitudinal change with risk of fatal strokes are unclear in older populations. Methods In this retrospective analysis, a total of 27,799 participants were included and followed up for a mean of 14.3 years (standard deviation =...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221098720 |
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| author | Zhi-bing Hu MD Qiong-qiong Zhong Msc Ze-xiong Lu Msc Feng Zhu Ph.D |
| author_facet | Zhi-bing Hu MD Qiong-qiong Zhong Msc Ze-xiong Lu Msc Feng Zhu Ph.D |
| author_sort | Zhi-bing Hu MD |
| collection | DOAJ |
| description | Background Associations of neutrophil-to-lymphocyte ratio (NLR) and its longitudinal change with risk of fatal strokes are unclear in older populations. Methods In this retrospective analysis, a total of 27,799 participants were included and followed up for a mean of 14.3 years (standard deviation = 3.2). 838 stroke deaths were recorded. Cox proportional hazards regression was used to assess associations of NLR with fatal strokes. Results Compared to those in the first quartile and after adjustment for a series of factors, the participants in the highest neutrophil quartile had an increased risk of fatal all stroke (adjusted hazard ratio (aHR) = 1.45, 95% confidence interval (CI), 1.18–1.79) and fatal ischaemic stroke (aHR = 1.58, 95% CI, 1.17–2.12). Restricted cubic splines showed an increased trend of relationship between the NLR and fatal all stroke. The participants with the highest NLR quartile had an increased risk of fatal all stroke (aHR = 1.52, 95% CI, 1.23–1.88) and fatal ischaemic stroke (aHR = 1.59, 95% CI, 1.13–2.26), respectively; Similar associations repeated after further C-reactive protein adjustment; a 21% and a 32% increased risk of fatal all stroke and fatal ischaemic stroke showed in a continuous variable model. Those in NLR change with 5% increase had a 70% increased risk of fatal all stroke (aHR = 1.70, 95%CI, 1.13–2.57), compared to those in stable (−5%∼5%). Conclusions Higher NLR was associated with an increased risk of fatal all stroke and fatal ischaemic stroke, and its longitudinal change increase of ≥ 5% was associated with an increased risk of fatal all stroke in a relatively healthy older population. |
| first_indexed | 2024-12-12T04:05:01Z |
| format | Article |
| id | doaj.art-9cc577ca7850433992e6d830f3a98c7b |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-12T04:05:01Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-9cc577ca7850433992e6d830f3a98c7b2022-12-22T00:38:47ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-05-012810.1177/10760296221098720Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older ChineseZhi-bing Hu MD0Qiong-qiong Zhong Msc1Ze-xiong Lu Msc2Feng Zhu Ph.D3 Department of Internal Medicine and Central laboratory, , Guangzhou, China Department of Public Health and Preventive Medicine, School of Medicine, , Guangzhou, China Department of Internal Medicine, , Sanya, China Department of Internal Medicine and Central laboratory, , Guangzhou, ChinaBackground Associations of neutrophil-to-lymphocyte ratio (NLR) and its longitudinal change with risk of fatal strokes are unclear in older populations. Methods In this retrospective analysis, a total of 27,799 participants were included and followed up for a mean of 14.3 years (standard deviation = 3.2). 838 stroke deaths were recorded. Cox proportional hazards regression was used to assess associations of NLR with fatal strokes. Results Compared to those in the first quartile and after adjustment for a series of factors, the participants in the highest neutrophil quartile had an increased risk of fatal all stroke (adjusted hazard ratio (aHR) = 1.45, 95% confidence interval (CI), 1.18–1.79) and fatal ischaemic stroke (aHR = 1.58, 95% CI, 1.17–2.12). Restricted cubic splines showed an increased trend of relationship between the NLR and fatal all stroke. The participants with the highest NLR quartile had an increased risk of fatal all stroke (aHR = 1.52, 95% CI, 1.23–1.88) and fatal ischaemic stroke (aHR = 1.59, 95% CI, 1.13–2.26), respectively; Similar associations repeated after further C-reactive protein adjustment; a 21% and a 32% increased risk of fatal all stroke and fatal ischaemic stroke showed in a continuous variable model. Those in NLR change with 5% increase had a 70% increased risk of fatal all stroke (aHR = 1.70, 95%CI, 1.13–2.57), compared to those in stable (−5%∼5%). Conclusions Higher NLR was associated with an increased risk of fatal all stroke and fatal ischaemic stroke, and its longitudinal change increase of ≥ 5% was associated with an increased risk of fatal all stroke in a relatively healthy older population.https://doi.org/10.1177/10760296221098720 |
| spellingShingle | Zhi-bing Hu MD Qiong-qiong Zhong Msc Ze-xiong Lu Msc Feng Zhu Ph.D Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese Clinical and Applied Thrombosis/Hemostasis |
| title | Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese |
| title_full | Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese |
| title_fullStr | Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese |
| title_full_unstemmed | Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese |
| title_short | Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese |
| title_sort | association of neutrophil to lymphocyte ratio with the risk of fatal stroke occurrence in older chinese |
| url | https://doi.org/10.1177/10760296221098720 |
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