Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study
The relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis. The prospective TRACK-TBI Pilot (Transforming Research and Clinical Know...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2023-03-01
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| Series: | Neurotrauma Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0060 |
| _version_ | 1797346181526847488 |
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| author | John K. Yue Firas H. Kobeissy Sonia Jain Xiaoying Sun Ryan R.L. Phelps Frederick K. Korley Raquel C. Gardner Adam R. Ferguson J. Russell Huie Andrea L.C. Schneider Zhihui Yang Haiyan Xu Cillian E. Lynch Hansen Deng Miri Rabinowitz Mary J. Vassar Sabrina R. Taylor Pratik Mukherjee Esther L. Yuh Amy J. Markowitz Ava M. Puccio David O. Okonkwo Ramon Diaz-Arrastia Geoffrey T. Manley Kevin K.W. Wang Collaboration group Collaboration group Neeraj Badjatia Brandon Foreman Shankar Gopinath Ramesh Grandhi Ruchira M. Jha Hester F. Lingsma Christopher Madden Debbie Y. Madhok Michael A. McCrea Randall Merchant Lindsay D. Nelson Laura B. Ngwenya Claudia S. Robertson Richard B. Rodgers Gabriela G. Satris David M. Schnyer Alex B. Valadka Thomas A. van Essen Ross Zafonte |
| author_facet | John K. Yue Firas H. Kobeissy Sonia Jain Xiaoying Sun Ryan R.L. Phelps Frederick K. Korley Raquel C. Gardner Adam R. Ferguson J. Russell Huie Andrea L.C. Schneider Zhihui Yang Haiyan Xu Cillian E. Lynch Hansen Deng Miri Rabinowitz Mary J. Vassar Sabrina R. Taylor Pratik Mukherjee Esther L. Yuh Amy J. Markowitz Ava M. Puccio David O. Okonkwo Ramon Diaz-Arrastia Geoffrey T. Manley Kevin K.W. Wang Collaboration group Collaboration group Neeraj Badjatia Brandon Foreman Shankar Gopinath Ramesh Grandhi Ruchira M. Jha Hester F. Lingsma Christopher Madden Debbie Y. Madhok Michael A. McCrea Randall Merchant Lindsay D. Nelson Laura B. Ngwenya Claudia S. Robertson Richard B. Rodgers Gabriela G. Satris David M. Schnyer Alex B. Valadka Thomas A. van Essen Ross Zafonte |
| author_sort | John K. Yue |
| collection | DOAJ |
| description | The relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis. The prospective TRACK-TBI Pilot (Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot) study enrolled TBI patients triaged to head computed tomography (CT) and received blood draw within 24?h of injury. Healthy controls (HCs) and orthopedic controls (OCs) were included. Thirty-one inflammatory markers were analyzed from plasma. Area under the receiver operating characteristic curve (AUC) was used to evaluate discriminatory ability. AUC >0.7 was considered acceptable. Criteria included: TBI diagnosis (vs. OC/HC); moderate/severe vs. mild TBI (Glasgow Coma Scale; GCS); radiographic TBI (CT positive vs. CT negative); 3- and 6-month Glasgow Outcome Scale-Extended (GOSE) dichotomized to death/greater relative disability versus less relative disability (GOSE 1?4/5?8); and incomplete versus full recovery (GOSE <8/?=?8). One-hundred sixty TBI subjects, 28 OCs, and 18 HCs were included. Markers discriminating TBI/OC: HMGB-1 (AUC?=?0.835), IL-1b (0.795), IL-16 (0.784), IL-7 (0.742), and TARC (0.731). Markers discriminating GCS 3?12/13?15: IL-6 (AUC?=?0.747), CRP (0.726), IL-15 (0.720), and SAA (0.716). Markers discriminating CT positive/CT negative: SAA (AUC?=?0.767), IL-6 (0.757), CRP (0.733), and IL-15 (0.724). At 3 months, IL-15 (AUC?=?0.738) and IL-2 (0.705) discriminated GOSE 5?8/1?4. At 6 months, IL-15 discriminated GOSE 1?4/5?8 (AUC?=?0.704) and GOSE <8/?=?8 (0.711); SAA discriminated GOSE 1?4/5?8 (0.704). We identified a profile of acute circulating inflammatory proteins with potential relevance for TBI diagnosis, severity differentiation, and prognosis. IL-15 and serum amyloid A are priority markers with acceptable discrimination across multiple diagnostic and outcome categories. Validation in larger prospective cohorts is needed. ClinicalTrials.gov Registration: NCT01565551 |
| first_indexed | 2024-03-08T11:28:06Z |
| format | Article |
| id | doaj.art-9cc684b83c2843f19ca58978f84419e7 |
| institution | Directory Open Access Journal |
| issn | 2689-288X |
| language | English |
| last_indexed | 2024-03-08T11:28:06Z |
| publishDate | 2023-03-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj.art-9cc684b83c2843f19ca58978f84419e72024-01-26T04:43:43ZengMary Ann LiebertNeurotrauma Reports2689-288X2023-03-014117118310.1089/NEUR.2022.0060Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot StudyJohn K. YueFiras H. KobeissySonia JainXiaoying SunRyan R.L. PhelpsFrederick K. KorleyRaquel C. GardnerAdam R. FergusonJ. Russell HuieAndrea L.C. SchneiderZhihui YangHaiyan XuCillian E. LynchHansen DengMiri RabinowitzMary J. VassarSabrina R. TaylorPratik MukherjeeEsther L. YuhAmy J. MarkowitzAva M. PuccioDavid O. OkonkwoRamon Diaz-ArrastiaGeoffrey T. ManleyKevin K.W. WangCollaboration groupCollaboration group0Neeraj BadjatiaBrandon ForemanShankar GopinathRamesh GrandhiRuchira M. JhaHester F. LingsmaChristopher MaddenDebbie Y. MadhokMichael A. McCreaRandall MerchantLindsay D. NelsonLaura B. NgwenyaClaudia S. RobertsonRichard B. RodgersGabriela G. SatrisDavid M. SchnyerAlex B. ValadkaThomas A. van EssenRoss Zafontethe TRACK-TBI InvestigatorsThe relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis. The prospective TRACK-TBI Pilot (Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot) study enrolled TBI patients triaged to head computed tomography (CT) and received blood draw within 24?h of injury. Healthy controls (HCs) and orthopedic controls (OCs) were included. Thirty-one inflammatory markers were analyzed from plasma. Area under the receiver operating characteristic curve (AUC) was used to evaluate discriminatory ability. AUC >0.7 was considered acceptable. Criteria included: TBI diagnosis (vs. OC/HC); moderate/severe vs. mild TBI (Glasgow Coma Scale; GCS); radiographic TBI (CT positive vs. CT negative); 3- and 6-month Glasgow Outcome Scale-Extended (GOSE) dichotomized to death/greater relative disability versus less relative disability (GOSE 1?4/5?8); and incomplete versus full recovery (GOSE <8/?=?8). One-hundred sixty TBI subjects, 28 OCs, and 18 HCs were included. Markers discriminating TBI/OC: HMGB-1 (AUC?=?0.835), IL-1b (0.795), IL-16 (0.784), IL-7 (0.742), and TARC (0.731). Markers discriminating GCS 3?12/13?15: IL-6 (AUC?=?0.747), CRP (0.726), IL-15 (0.720), and SAA (0.716). Markers discriminating CT positive/CT negative: SAA (AUC?=?0.767), IL-6 (0.757), CRP (0.733), and IL-15 (0.724). At 3 months, IL-15 (AUC?=?0.738) and IL-2 (0.705) discriminated GOSE 5?8/1?4. At 6 months, IL-15 discriminated GOSE 1?4/5?8 (AUC?=?0.704) and GOSE <8/?=?8 (0.711); SAA discriminated GOSE 1?4/5?8 (0.704). We identified a profile of acute circulating inflammatory proteins with potential relevance for TBI diagnosis, severity differentiation, and prognosis. IL-15 and serum amyloid A are priority markers with acceptable discrimination across multiple diagnostic and outcome categories. Validation in larger prospective cohorts is needed. ClinicalTrials.gov Registration: NCT01565551https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0060acute phase reactantalarmincytokineneuroinflammationprognosistraumatic brain injury |
| spellingShingle | John K. Yue Firas H. Kobeissy Sonia Jain Xiaoying Sun Ryan R.L. Phelps Frederick K. Korley Raquel C. Gardner Adam R. Ferguson J. Russell Huie Andrea L.C. Schneider Zhihui Yang Haiyan Xu Cillian E. Lynch Hansen Deng Miri Rabinowitz Mary J. Vassar Sabrina R. Taylor Pratik Mukherjee Esther L. Yuh Amy J. Markowitz Ava M. Puccio David O. Okonkwo Ramon Diaz-Arrastia Geoffrey T. Manley Kevin K.W. Wang Collaboration group Collaboration group Neeraj Badjatia Brandon Foreman Shankar Gopinath Ramesh Grandhi Ruchira M. Jha Hester F. Lingsma Christopher Madden Debbie Y. Madhok Michael A. McCrea Randall Merchant Lindsay D. Nelson Laura B. Ngwenya Claudia S. Robertson Richard B. Rodgers Gabriela G. Satris David M. Schnyer Alex B. Valadka Thomas A. van Essen Ross Zafonte Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study Neurotrauma Reports acute phase reactant alarmin cytokine neuroinflammation prognosis traumatic brain injury |
| title | Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study |
| title_full | Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study |
| title_fullStr | Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study |
| title_full_unstemmed | Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study |
| title_short | Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study |
| title_sort | neuroinflammatory biomarkers for traumatic brain injury diagnosis and prognosis a track tbi pilot study |
| topic | acute phase reactant alarmin cytokine neuroinflammation prognosis traumatic brain injury |
| url | https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0060 |
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