A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis

A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis

Ferroptosis, an iron-dependent form of programmed cell death, has excellent potential as an anti-cancer therapeutic strategy in different types of tumors, especially in RAS-mutated ones. However, the function of ferroptosis for inhibiting neuroblastoma, a common child malignant tumor with minimal tr...

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Bibliographic Details
Main Authors: Ruiqing Lu, Yinan Jiang, Xianxin Lai, Shujie Liu, Litao Sun, Zhong-Wei Zhou
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
FTH
ROS
ferroptosis
neuroblastoma
Online Access:https://www.mdpi.com/1422-0067/22/16/8898

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