Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5
The incidence of hypertension and diabetes is increasing, it is reported that adipocytokines might be involved in the pathogenesis of diabetes and hypertension. We aimed to investigate the features of adipocytokines, included of Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) pati...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-10-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2018.1529779 |
| _version_ | 1797681386694377472 |
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| author | Baoxin Li Qi Yao Shuqin Guo Shuang Ma Yuehua Dong Huanhuan Xin He Wang Lifang Liu Wenlong Chang Yunliang Zhang |
| author_facet | Baoxin Li Qi Yao Shuqin Guo Shuang Ma Yuehua Dong Huanhuan Xin He Wang Lifang Liu Wenlong Chang Yunliang Zhang |
| author_sort | Baoxin Li |
| collection | DOAJ |
| description | The incidence of hypertension and diabetes is increasing, it is reported that adipocytokines might be involved in the pathogenesis of diabetes and hypertension. We aimed to investigate the features of adipocytokines, included of Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) patients with hypertension, simultaneously analyzed the connection of the alteration of adipocytokines with blood pressure and glucose. 424 patients with T2DM and 90 healthy subjects were included in the study. The patients with T2DM were divided into 4 groups based on the blood pressure. The levels of adipocytokines (Leptin, Irisin, LGR4, and Sfrp5) were determined by enzyme-linked immunosorbent assay (ELISA). Significantly higher levels of Leptin and lower levels of Irisin, LGR4 and Sfrp5 were seen in patients with diabetes compared with non-diabetes (P < 0.05), the mean values of Leptin level was ascending and Irisin, LGR4, and Sfrp5 levels were declining with promoting of blood pressure in hypertension as compared to the non-hypertension with diabetic patients. Multiple stepwise linear regression analysis showed that the concentrations of Leptin, Irisin, Sfrp5, and LGR4 were found to be closely associated with the control of blood pressure and glucose. Conclusion: Four adipocytokines might play different roles and closely relate to the occurrence and development of diabetes and hypertension. |
| first_indexed | 2024-03-11T23:44:12Z |
| format | Article |
| id | doaj.art-9cc9043bc8cb4aaa98e4708f4600cabd |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:44:12Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-9cc9043bc8cb4aaa98e4708f4600cabd2023-09-19T15:19:27ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-10-0141764565010.1080/10641963.2018.15297791529779Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5Baoxin Li0Qi Yao1Shuqin Guo2Shuang Ma3Yuehua Dong4Huanhuan Xin5He Wang6Lifang Liu7Wenlong Chang8Yunliang Zhang9Baoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalBaoding NO.1 Central HospitalThe incidence of hypertension and diabetes is increasing, it is reported that adipocytokines might be involved in the pathogenesis of diabetes and hypertension. We aimed to investigate the features of adipocytokines, included of Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) patients with hypertension, simultaneously analyzed the connection of the alteration of adipocytokines with blood pressure and glucose. 424 patients with T2DM and 90 healthy subjects were included in the study. The patients with T2DM were divided into 4 groups based on the blood pressure. The levels of adipocytokines (Leptin, Irisin, LGR4, and Sfrp5) were determined by enzyme-linked immunosorbent assay (ELISA). Significantly higher levels of Leptin and lower levels of Irisin, LGR4 and Sfrp5 were seen in patients with diabetes compared with non-diabetes (P < 0.05), the mean values of Leptin level was ascending and Irisin, LGR4, and Sfrp5 levels were declining with promoting of blood pressure in hypertension as compared to the non-hypertension with diabetic patients. Multiple stepwise linear regression analysis showed that the concentrations of Leptin, Irisin, Sfrp5, and LGR4 were found to be closely associated with the control of blood pressure and glucose. Conclusion: Four adipocytokines might play different roles and closely relate to the occurrence and development of diabetes and hypertension.http://dx.doi.org/10.1080/10641963.2018.1529779diabeteshypertensionleptinirisinlgr4sfrp5 |
| spellingShingle | Baoxin Li Qi Yao Shuqin Guo Shuang Ma Yuehua Dong Huanhuan Xin He Wang Lifang Liu Wenlong Chang Yunliang Zhang Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5 Clinical and Experimental Hypertension diabetes hypertension leptin irisin lgr4 sfrp5 |
| title | Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5 |
| title_full | Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5 |
| title_fullStr | Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5 |
| title_full_unstemmed | Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5 |
| title_short | Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5 |
| title_sort | type 2 diabetes with hypertensive patients results in changes to features of adipocytokines leptin irisin lgr4 and sfrp5 |
| topic | diabetes hypertension leptin irisin lgr4 sfrp5 |
| url | http://dx.doi.org/10.1080/10641963.2018.1529779 |
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