The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i>
The isolation and characterization of bacteriophages for the treatment of infections caused by the multidrug resistant pathogen <i>Stenotrophomonas maltophilia</i> is imperative as nosocomial and community-acquired infections are rapidly increasing in prevalence. This increase is largely...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1057 |
| _version_ | 1797531533390643200 |
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| author | Jaclyn G. McCutcheon Jonathan J. Dennis |
| author_facet | Jaclyn G. McCutcheon Jonathan J. Dennis |
| author_sort | Jaclyn G. McCutcheon |
| collection | DOAJ |
| description | The isolation and characterization of bacteriophages for the treatment of infections caused by the multidrug resistant pathogen <i>Stenotrophomonas maltophilia</i> is imperative as nosocomial and community-acquired infections are rapidly increasing in prevalence. This increase is largely due to the numerous virulence factors and antimicrobial resistance genes encoded by this bacterium. Research on <i>S. maltophilia</i> phages to date has focused on the isolation and in vitro characterization of novel phages, often including genomic characterization, from the environment or by induction from bacterial strains. This review summarizes the clinical significance, virulence factors, and antimicrobial resistance mechanisms of <i>S. maltophilia</i>, as well as all phages isolated and characterized to date and strategies for their use. We further address the limited in vivo phage therapy studies conducted against this bacterium and discuss the future research needed to spearhead phages as an alternative treatment option against multidrug resistant <i>S. maltophilia</i>. |
| first_indexed | 2024-03-10T10:46:04Z |
| format | Article |
| id | doaj.art-9cc9cc094f254f7dad43f2108ee40c3d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:46:04Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-9cc9cc094f254f7dad43f2108ee40c3d2023-11-21T22:37:39ZengMDPI AGViruses1999-49152021-06-01136105710.3390/v13061057The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i>Jaclyn G. McCutcheon0Jonathan J. Dennis1Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, CanadaDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, CanadaThe isolation and characterization of bacteriophages for the treatment of infections caused by the multidrug resistant pathogen <i>Stenotrophomonas maltophilia</i> is imperative as nosocomial and community-acquired infections are rapidly increasing in prevalence. This increase is largely due to the numerous virulence factors and antimicrobial resistance genes encoded by this bacterium. Research on <i>S. maltophilia</i> phages to date has focused on the isolation and in vitro characterization of novel phages, often including genomic characterization, from the environment or by induction from bacterial strains. This review summarizes the clinical significance, virulence factors, and antimicrobial resistance mechanisms of <i>S. maltophilia</i>, as well as all phages isolated and characterized to date and strategies for their use. We further address the limited in vivo phage therapy studies conducted against this bacterium and discuss the future research needed to spearhead phages as an alternative treatment option against multidrug resistant <i>S. maltophilia</i>.https://www.mdpi.com/1999-4915/13/6/1057<i>Stenotrophomonas maltophilia</i>bacteriophagephage therapyantibiotic resistance |
| spellingShingle | Jaclyn G. McCutcheon Jonathan J. Dennis The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i> Viruses <i>Stenotrophomonas maltophilia</i> bacteriophage phage therapy antibiotic resistance |
| title | The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i> |
| title_full | The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i> |
| title_fullStr | The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i> |
| title_full_unstemmed | The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i> |
| title_short | The Potential of Phage Therapy against the Emerging Opportunistic Pathogen <i>Stenotrophomonas maltophilia</i> |
| title_sort | potential of phage therapy against the emerging opportunistic pathogen i stenotrophomonas maltophilia i |
| topic | <i>Stenotrophomonas maltophilia</i> bacteriophage phage therapy antibiotic resistance |
| url | https://www.mdpi.com/1999-4915/13/6/1057 |
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