The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series
Abstract Background Brain metastasis (BM) of colorectal cancer is a disease with a poor prognosis of only a few months survival. However, it is difficult to estimate the individual prognosis of each patient due to the lack of definitive prognosis parameters. The number of metastases and the Karnofsk...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-09435-1 |
| _version_ | 1818773977414238208 |
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| author | Caroline Sander Clara Frydrychowicz Gordian Prasse Sabine Taubenheim Felix Arlt Jürgen Meixensberger Michael Karl Fehrenbach |
| author_facet | Caroline Sander Clara Frydrychowicz Gordian Prasse Sabine Taubenheim Felix Arlt Jürgen Meixensberger Michael Karl Fehrenbach |
| author_sort | Caroline Sander |
| collection | DOAJ |
| description | Abstract Background Brain metastasis (BM) of colorectal cancer is a disease with a poor prognosis of only a few months survival. However, it is difficult to estimate the individual prognosis of each patient due to the lack of definitive prognosis parameters. The number of metastases and the Karnofsky performance score are known predictors for survival. We investigated whether or not the neurological performance score and the tumor volumetrics are equally suitable predictors for survival. Design All patients with histologically diagnosed BM linked to colorectal cancer between 2012 and March 2020 were reviewed. The Medical Research Council Neurological Performance Score was used to quantify neurological performance. Univariate analysis with Kaplan-Meier estimate and log-rank test was performed. Survival prediction and multivariate analysis were performed employing Cox proportional hazard regression. Results Twenty-five patients were included in our analysis with an overall survival of 4.9 months after surgery of the BM. Survival decreased in the univariate analysis with increasing postoperative neurological performance score, low Karnofsky performance score, absence of radiation therapy and radiation therapy modality. The neurological performance score is a reliable scoring parameter for estimating the prognostic course analogous to the Karnofsky performance score. Neither preoperative nor post resection residual tumor volume had any impact on overall survival in our small cohort. Conclusion Our data suggest that the postoperative neurological performance is a valuable prognostic factor for colorectal cancer patients with BM. Tumor volumetrics show no correlation to survival. Further investigations with a larger number of cases are mandatory. |
| first_indexed | 2024-12-18T10:33:49Z |
| format | Article |
| id | doaj.art-9cca8759f04f4230b5977f823ef17442 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-18T10:33:49Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9cca8759f04f4230b5977f823ef174422022-12-21T21:10:48ZengBMCBMC Cancer1471-24072022-03-0122111010.1186/s12885-022-09435-1The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case seriesCaroline Sander0Clara Frydrychowicz1Gordian Prasse2Sabine Taubenheim3Felix Arlt4Jürgen Meixensberger5Michael Karl Fehrenbach6Department of Neurosurgery, University Hospital LeipzigDivision of Neuropathology, University Hospital LeipzigInstitute of Neuroradiology, University Hospital LeipzigLeipzig Cancer Registry, University Hospital LeipzigDepartment of Neurosurgery, University Hospital LeipzigDepartment of Neurosurgery, University Hospital LeipzigDepartment of Neurosurgery, University Hospital LeipzigAbstract Background Brain metastasis (BM) of colorectal cancer is a disease with a poor prognosis of only a few months survival. However, it is difficult to estimate the individual prognosis of each patient due to the lack of definitive prognosis parameters. The number of metastases and the Karnofsky performance score are known predictors for survival. We investigated whether or not the neurological performance score and the tumor volumetrics are equally suitable predictors for survival. Design All patients with histologically diagnosed BM linked to colorectal cancer between 2012 and March 2020 were reviewed. The Medical Research Council Neurological Performance Score was used to quantify neurological performance. Univariate analysis with Kaplan-Meier estimate and log-rank test was performed. Survival prediction and multivariate analysis were performed employing Cox proportional hazard regression. Results Twenty-five patients were included in our analysis with an overall survival of 4.9 months after surgery of the BM. Survival decreased in the univariate analysis with increasing postoperative neurological performance score, low Karnofsky performance score, absence of radiation therapy and radiation therapy modality. The neurological performance score is a reliable scoring parameter for estimating the prognostic course analogous to the Karnofsky performance score. Neither preoperative nor post resection residual tumor volume had any impact on overall survival in our small cohort. Conclusion Our data suggest that the postoperative neurological performance is a valuable prognostic factor for colorectal cancer patients with BM. Tumor volumetrics show no correlation to survival. Further investigations with a larger number of cases are mandatory.https://doi.org/10.1186/s12885-022-09435-1Colorectal cancerBrain metastasisNeurologic performancePrognostic factorsRadiotherapyVolumetrics |
| spellingShingle | Caroline Sander Clara Frydrychowicz Gordian Prasse Sabine Taubenheim Felix Arlt Jürgen Meixensberger Michael Karl Fehrenbach The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series BMC Cancer Colorectal cancer Brain metastasis Neurologic performance Prognostic factors Radiotherapy Volumetrics |
| title | The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series |
| title_full | The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series |
| title_fullStr | The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series |
| title_full_unstemmed | The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series |
| title_short | The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series |
| title_sort | impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer a retrospective single center case series |
| topic | Colorectal cancer Brain metastasis Neurologic performance Prognostic factors Radiotherapy Volumetrics |
| url | https://doi.org/10.1186/s12885-022-09435-1 |
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