Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature review
The aim of the work is to analyze all available literature data on the role of secondary cytoreduction, its effectiveness and safety in the recurrence of ovarian cancer (ОС) with isolated lymph node (LN) lesion.The importance and place of secondary cytoreduction in the combined treatment of recurren...
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| Format: | Article |
| Language: | Russian |
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“ABV-press” Publishing house”, LLC
2022-04-01
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| Series: | Тазовая хирургия и онкология |
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| Online Access: | https://ok.abvpress.ru/jour/article/view/530 |
| _version_ | 1797757056686489600 |
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| author | O. A. Egenov A. S. Tjulandina E. A. Suleymanov I. S. Stilidi |
| author_facet | O. A. Egenov A. S. Tjulandina E. A. Suleymanov I. S. Stilidi |
| author_sort | O. A. Egenov |
| collection | DOAJ |
| description | The aim of the work is to analyze all available literature data on the role of secondary cytoreduction, its effectiveness and safety in the recurrence of ovarian cancer (ОС) with isolated lymph node (LN) lesion.The importance and place of secondary cytoreduction in the combined treatment of recurrent ОС is one of the most controversial topics. The lesion of the LN in recurrent Ос varies from 12 % to 37 %, but an isolated recurrence in the LN is a very rare occurrence, about 5 %. The most common localization in recurrent ОС with isolated LN lesion is the paraaortic LN.The results of this literature review suggest that isolated Ln lesion should be clearly distinguished from recurrence at other sites (such as peritoneal and parenchymal), since patients with isolated recurrence in the LN have a relatively indolent course of the disease. The frequency of complete cytoreduction according to the available data of retrospective studies reaches 100 %. Paraaortic and pelvic lymph node dissection without a macroscopically detectable residual tumor in combination with postoperative systemic chemotherapy leads to improved survival rates compared only with systemic drug treatment of patients with isolated LN lesion in recurrent ОС. median survival from the moment of relapse detection and overall survival varies from about 2.5 to 4 years and >5 years, respectively. Systemic paraaortic and pelvic lymph node dissection is preferable compared to selective lymphadenectomy, as it is accompanied by an increase in progression-free survival, although it doesn’t significantly prolong overall survival. |
| first_indexed | 2024-03-12T18:10:31Z |
| format | Article |
| id | doaj.art-9ccef1a0d4554871854d140677c6936f |
| institution | Directory Open Access Journal |
| issn | 2686-9594 |
| language | Russian |
| last_indexed | 2024-03-12T18:10:31Z |
| publishDate | 2022-04-01 |
| publisher | “ABV-press” Publishing house”, LLC |
| record_format | Article |
| series | Тазовая хирургия и онкология |
| spelling | doaj.art-9ccef1a0d4554871854d140677c6936f2023-08-02T09:16:27Zrus“ABV-press” Publishing house”, LLCТазовая хирургия и онкология2686-95942022-04-01121586610.17650/2686-9594-2022-12-1-58-66383Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature reviewO. A. Egenov0A. S. Tjulandina1E. A. Suleymanov2I. S. Stilidi3N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaN.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaMinistry of Health of Chechen RepublicN.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaThe aim of the work is to analyze all available literature data on the role of secondary cytoreduction, its effectiveness and safety in the recurrence of ovarian cancer (ОС) with isolated lymph node (LN) lesion.The importance and place of secondary cytoreduction in the combined treatment of recurrent ОС is one of the most controversial topics. The lesion of the LN in recurrent Ос varies from 12 % to 37 %, but an isolated recurrence in the LN is a very rare occurrence, about 5 %. The most common localization in recurrent ОС with isolated LN lesion is the paraaortic LN.The results of this literature review suggest that isolated Ln lesion should be clearly distinguished from recurrence at other sites (such as peritoneal and parenchymal), since patients with isolated recurrence in the LN have a relatively indolent course of the disease. The frequency of complete cytoreduction according to the available data of retrospective studies reaches 100 %. Paraaortic and pelvic lymph node dissection without a macroscopically detectable residual tumor in combination with postoperative systemic chemotherapy leads to improved survival rates compared only with systemic drug treatment of patients with isolated LN lesion in recurrent ОС. median survival from the moment of relapse detection and overall survival varies from about 2.5 to 4 years and >5 years, respectively. Systemic paraaortic and pelvic lymph node dissection is preferable compared to selective lymphadenectomy, as it is accompanied by an increase in progression-free survival, although it doesn’t significantly prolong overall survival.https://ok.abvpress.ru/jour/article/view/530platinum-sensitive relapsesecondary cytoreductioncomplete cytoreductionincomplete cytoreductionretroperitoneal lymph node dissectionpelvic lymph node dissection |
| spellingShingle | O. A. Egenov A. S. Tjulandina E. A. Suleymanov I. S. Stilidi Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature review Тазовая хирургия и онкология platinum-sensitive relapse secondary cytoreduction complete cytoreduction incomplete cytoreduction retroperitoneal lymph node dissection pelvic lymph node dissection |
| title | Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature review |
| title_full | Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature review |
| title_fullStr | Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature review |
| title_full_unstemmed | Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature review |
| title_short | Paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion: a literature review |
| title_sort | paraaortic and pelvic lymph node dissection in the combined treatment of recurrent ovarian cancer with isolated lymph node lesion a literature review |
| topic | platinum-sensitive relapse secondary cytoreduction complete cytoreduction incomplete cytoreduction retroperitoneal lymph node dissection pelvic lymph node dissection |
| url | https://ok.abvpress.ru/jour/article/view/530 |
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