Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked. Hence, the neuroinflammation is a relevant ta...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=9;spage=1418;epage=1421;aulast=Foucault-Fruchard |
| _version_ | 1818454636989775872 |
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| author | Laura Foucault-Fruchard Daniel Antier |
| author_facet | Laura Foucault-Fruchard Daniel Antier |
| author_sort | Laura Foucault-Fruchard |
| collection | DOAJ |
| description | Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked. Hence, the neuroinflammation is a relevant target for the management of the neurodegenerative diseases given that, to date, there is no treatment to stop neuronal loss. Several studies have investigated the potential effects of activators of alpha 7 nicotinic acetylcholine receptors in animal models of neurodegenerative diseases. These receptors are widely distributed in the central nervous system. After activation, they seem to mediate the cholinergic anti-inflammatory pathway in the brain. This anti-inflammatory pathway, first described in periphery, regulates activation of microglial cells considered as the resident macrophage population of the central nervous system. In this article, we shortly review the agonists of the alpha 7 nicotinic acetylcholine receptors that have been evaluated in vivo and we focused on the selective positive allosteric modulators of these receptors. These compounds represent a key element to enhance receptor activity only in the presence of the endogenous agonist. |
| first_indexed | 2024-12-14T21:58:02Z |
| format | Article |
| id | doaj.art-9cd0d39fbc95446c9731dd8d2a935d0f |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-14T21:58:02Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-9cd0d39fbc95446c9731dd8d2a935d0f2022-12-21T22:46:04ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-011291418142110.4103/1673-5374.215244Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseasesLaura Foucault-FruchardDaniel AntierNeurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked. Hence, the neuroinflammation is a relevant target for the management of the neurodegenerative diseases given that, to date, there is no treatment to stop neuronal loss. Several studies have investigated the potential effects of activators of alpha 7 nicotinic acetylcholine receptors in animal models of neurodegenerative diseases. These receptors are widely distributed in the central nervous system. After activation, they seem to mediate the cholinergic anti-inflammatory pathway in the brain. This anti-inflammatory pathway, first described in periphery, regulates activation of microglial cells considered as the resident macrophage population of the central nervous system. In this article, we shortly review the agonists of the alpha 7 nicotinic acetylcholine receptors that have been evaluated in vivo and we focused on the selective positive allosteric modulators of these receptors. These compounds represent a key element to enhance receptor activity only in the presence of the endogenous agonist.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=9;spage=1418;epage=1421;aulast=Foucault-Fruchardα7 nicotinic receptors; cholinergic anti-inflammatory pathway; Alzheimer′s disease; Huntington′s disease; Parkinson′s disease; neuroinflammation; neurodegeneration; positive allosteric modulators |
| spellingShingle | Laura Foucault-Fruchard Daniel Antier Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases Neural Regeneration Research α7 nicotinic receptors; cholinergic anti-inflammatory pathway; Alzheimer′s disease; Huntington′s disease; Parkinson′s disease; neuroinflammation; neurodegeneration; positive allosteric modulators |
| title | Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases |
| title_full | Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases |
| title_fullStr | Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases |
| title_full_unstemmed | Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases |
| title_short | Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases |
| title_sort | therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases |
| topic | α7 nicotinic receptors; cholinergic anti-inflammatory pathway; Alzheimer′s disease; Huntington′s disease; Parkinson′s disease; neuroinflammation; neurodegeneration; positive allosteric modulators |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=9;spage=1418;epage=1421;aulast=Foucault-Fruchard |
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