Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus

Abstract Background Poor glycaemic control is associated with a greater risk of development of heart failure in diabetic patients. We aimed to study the prevalence of left ventricular (LV) systolic and diastolic dysfunction in asymptomatic patients with new-onset type 2 DM. We conducted a cross-sect...

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Main Authors: K. M. Hassan Ayman, A. Abdallah Mahmoud, A. Abdel-Mageed Eman, Sayed Marwa, M. Soliman Mona, T. Kishk Yehia
Format: Article
Language:English
Published: SpringerOpen 2021-02-01
Series:The Egyptian Journal of Internal Medicine
Online Access:https://doi.org/10.1186/s43162-021-00037-0
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author K. M. Hassan Ayman
A. Abdallah Mahmoud
A. Abdel-Mageed Eman
Sayed Marwa
M. Soliman Mona
T. Kishk Yehia
author_facet K. M. Hassan Ayman
A. Abdallah Mahmoud
A. Abdel-Mageed Eman
Sayed Marwa
M. Soliman Mona
T. Kishk Yehia
author_sort K. M. Hassan Ayman
collection DOAJ
description Abstract Background Poor glycaemic control is associated with a greater risk of development of heart failure in diabetic patients. We aimed to study the prevalence of left ventricular (LV) systolic and diastolic dysfunction in asymptomatic patients with new-onset type 2 DM. We conducted a cross-sectional study including patients with newly diagnosed (within 1 year) type 2 DM; all patients were between the ages of 30 and 60 years, normotensive and clinically asymptomatic and attended the outpatient clinic of the endocrinology unit at a university hospital between March 2016 and June 2017. Demographic characteristics, clinical risk factors and waist-hip ratio (WHR) were assessed. Blood samples for laboratory analysis were obtained. Detailed echocardiography was performed to evaluate systolic and diastolic function. Results A total of 100 patients were included. Sixty-one percent had diastolic dysfunction with preserved ejection fraction. Left ventricular diastolic dysfunction (LVDD) was more prevalent in diabetic patients with HbA1c ≥ 8.1 (75%) Patients with LVDD had significant dyslipidaemia in comparison to those without LVDD. Multivariate logistic regression analysis showed that WHR and HbA1c levels are the only predictors of impaired diastolic function in patients with new-onset DM. Kaplan-Meier survival curves showed a significant correlation between the incidence of diastolic dysfunction and the duration of DM, with higher incidence with HbA1c ≥ 8.1. Conclusions Diastolic dysfunction is highly prevalent in patients with newly diagnosed DM and is positively correlated with HbA1c level, obesity, dyslipidaemia and the duration of diabetes.
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spelling doaj.art-9cd1186730d04c7c93fbd0b7e6e4d8c42022-12-21T23:06:11ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982021-02-0133111110.1186/s43162-021-00037-0Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitusK. M. Hassan Ayman0A. Abdallah Mahmoud1A. Abdel-Mageed Eman2Sayed Marwa3M. Soliman Mona4T. Kishk Yehia5Department of Cardiovascular Medicine, Faculty of Medicine, Assiut University HospitalsDepartment of Cardiovascular Medicine, Faculty of Medicine, Assiut University HospitalsDepartment of Cardiovascular Medicine, Faculty of Medicine, Assiut University HospitalsDepartment of Cardiovascular Medicine, Faculty of Medicine, Assiut University HospitalsDepartment of Internal Medicine, Faculty of Medicine, Assiut University HospitalsDepartment of Cardiovascular Medicine, Faculty of Medicine, Assiut University HospitalsAbstract Background Poor glycaemic control is associated with a greater risk of development of heart failure in diabetic patients. We aimed to study the prevalence of left ventricular (LV) systolic and diastolic dysfunction in asymptomatic patients with new-onset type 2 DM. We conducted a cross-sectional study including patients with newly diagnosed (within 1 year) type 2 DM; all patients were between the ages of 30 and 60 years, normotensive and clinically asymptomatic and attended the outpatient clinic of the endocrinology unit at a university hospital between March 2016 and June 2017. Demographic characteristics, clinical risk factors and waist-hip ratio (WHR) were assessed. Blood samples for laboratory analysis were obtained. Detailed echocardiography was performed to evaluate systolic and diastolic function. Results A total of 100 patients were included. Sixty-one percent had diastolic dysfunction with preserved ejection fraction. Left ventricular diastolic dysfunction (LVDD) was more prevalent in diabetic patients with HbA1c ≥ 8.1 (75%) Patients with LVDD had significant dyslipidaemia in comparison to those without LVDD. Multivariate logistic regression analysis showed that WHR and HbA1c levels are the only predictors of impaired diastolic function in patients with new-onset DM. Kaplan-Meier survival curves showed a significant correlation between the incidence of diastolic dysfunction and the duration of DM, with higher incidence with HbA1c ≥ 8.1. Conclusions Diastolic dysfunction is highly prevalent in patients with newly diagnosed DM and is positively correlated with HbA1c level, obesity, dyslipidaemia and the duration of diabetes.https://doi.org/10.1186/s43162-021-00037-0
spellingShingle K. M. Hassan Ayman
A. Abdallah Mahmoud
A. Abdel-Mageed Eman
Sayed Marwa
M. Soliman Mona
T. Kishk Yehia
Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus
The Egyptian Journal of Internal Medicine
title Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus
title_full Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus
title_fullStr Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus
title_full_unstemmed Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus
title_short Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus
title_sort correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new onset type 2 diabetes mellitus
url https://doi.org/10.1186/s43162-021-00037-0
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