RAD21 Confers Poor Prognosis and Affects Ovarian Cancer Sensitivity to Poly(ADP-Ribose)Polymerase Inhibitors Through DNA Damage Repair

RAD21 Confers Poor Prognosis and Affects Ovarian Cancer Sensitivity to Poly(ADP-Ribose)Polymerase Inhibitors Through DNA Damage Repair

BackgroundPoly(ADP-ribose)polymerase (PARP) inhibitors are a class of molecular-targeted cancer drugs. Synthetic lethality is a phenomenon that renders homologous recombination repair defective cells more sensitive to PARP inhibitors. As a component of the cohesin complex, RAD21 regulates DNA damage...

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Bibliographic Details
Main Authors: Rui Gou, Xiao Li, Hui Dong, Yuexin Hu, Ouxuan Liu, Juanjuan Liu, Bei Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
RAD21
ovarian cancer
PARP inhibitor
DNA damage repair
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.936550/full

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