Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)—A specialised peripheral chemoreceptor. Central to CB O<sub>2</sub>-sensing is their unique mitochondria but the link between mitochondrial inhibition and cellular stimulation...

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Bibliographic Details
Main Authors: Agnieszka Swiderska, Andrew M. Coney, Abdulaziz A. Alzahrani, Hayyaf S. Aldossary, Nikolaos Batis, Clare J. Ray, Prem Kumar, Andrew P. Holmes
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Antioxidants
Subjects:
carotid body
hypoxia
succinate
mitochondrial reactive oxygen species
succinate dehydrogenase
hypoxic ventilatory response
Online Access:https://www.mdpi.com/2076-3921/10/6/840

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