Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection
Abstract Objective To determine perinatal and pregnancy outcomes of Acinetobacter baumannii infection using clinicopathologic material from pregnant women, neonates, and perinatal postmortem examinations with positive cultures. Study Design This is a retrospective record re...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2013-02-01
|
| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1334460 |
| _version_ | 1828486893800521728 |
|---|---|
| author | Mai He Stefan Kostadinov Fusun Gundogan Judith Struminsky Halit Pinar C. James Sung |
| author_facet | Mai He Stefan Kostadinov Fusun Gundogan Judith Struminsky Halit Pinar C. James Sung |
| author_sort | Mai He |
| collection | DOAJ |
| description | Abstract
Objective To determine perinatal and pregnancy outcomes of Acinetobacter baumannii infection using clinicopathologic material from pregnant women, neonates, and perinatal postmortem examinations with positive cultures.
Study Design This is a retrospective record review with placental and postmortem examination.
Results During a 5-year period, 40 positive cultures were found. Three pregnancies with positive cultures close in the peripartum period were all associated with adverse outcomes including spontaneous abortion, preterm labor, and one full-term birth with histological chorioamnionitis. Two positive cultures were found in preterm neonates in the neonatal intensive care unit. Two of three cases of perinatal death grew pure cultures from blood and/or fetal tissue with placental or fetal examination demonstrating evidence of infection/inflammation with fetal inflammatory response.
Conclusion This is the first case series report of A. baumannii-positive cultures in maternal, fetal, and neonatal specimen, with histopathologic evidence of infection. The results suggest a significant role of A. baumannii infection in adverse pregnancy and perinatal outcomes. |
| first_indexed | 2024-12-11T09:41:09Z |
| format | Article |
| id | doaj.art-9cd5a8af21794e499f6a90a7783dbf52 |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-11T09:41:09Z |
| publishDate | 2013-02-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-9cd5a8af21794e499f6a90a7783dbf522022-12-22T01:12:40ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052013-02-01030105105610.1055/s-0033-1334460Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii InfectionMai He0Stefan Kostadinov1Fusun Gundogan2Judith Struminsky3Halit Pinar4C. James Sung5Department of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, Rhode IslandDepartment of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, Rhode IslandDepartment of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, Rhode IslandDepartment of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, Rhode IslandDepartment of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, Rhode IslandDepartment of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, Rhode IslandAbstract Objective To determine perinatal and pregnancy outcomes of Acinetobacter baumannii infection using clinicopathologic material from pregnant women, neonates, and perinatal postmortem examinations with positive cultures. Study Design This is a retrospective record review with placental and postmortem examination. Results During a 5-year period, 40 positive cultures were found. Three pregnancies with positive cultures close in the peripartum period were all associated with adverse outcomes including spontaneous abortion, preterm labor, and one full-term birth with histological chorioamnionitis. Two positive cultures were found in preterm neonates in the neonatal intensive care unit. Two of three cases of perinatal death grew pure cultures from blood and/or fetal tissue with placental or fetal examination demonstrating evidence of infection/inflammation with fetal inflammatory response. Conclusion This is the first case series report of A. baumannii-positive cultures in maternal, fetal, and neonatal specimen, with histopathologic evidence of infection. The results suggest a significant role of A. baumannii infection in adverse pregnancy and perinatal outcomes.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1334460autopsystillbirthplacentapregnancybacterial culture |
| spellingShingle | Mai He Stefan Kostadinov Fusun Gundogan Judith Struminsky Halit Pinar C. James Sung Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection American Journal of Perinatology Reports autopsy stillbirth placenta pregnancy bacterial culture |
| title | Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection |
| title_full | Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection |
| title_fullStr | Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection |
| title_full_unstemmed | Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection |
| title_short | Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection |
| title_sort | pregnancy and perinatal outcomes associated with acinetobacter baumannii infection |
| topic | autopsy stillbirth placenta pregnancy bacterial culture |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1334460 |
| work_keys_str_mv | AT maihe pregnancyandperinataloutcomesassociatedwithacinetobacterbaumanniiinfection AT stefankostadinov pregnancyandperinataloutcomesassociatedwithacinetobacterbaumanniiinfection AT fusungundogan pregnancyandperinataloutcomesassociatedwithacinetobacterbaumanniiinfection AT judithstruminsky pregnancyandperinataloutcomesassociatedwithacinetobacterbaumanniiinfection AT halitpinar pregnancyandperinataloutcomesassociatedwithacinetobacterbaumanniiinfection AT cjamessung pregnancyandperinataloutcomesassociatedwithacinetobacterbaumanniiinfection |