Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis
Cryptosporidium is one of the major causes of diarrhea in HIV-positive patients. The aim of this study is to systematically review and meta-analyze the prevalence of Cryptosporidium in these patients. PubMed, Science Direct, Google Scholar, Web of Science, Cochrane and Ovid databases were searched f...
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| Format: | Article |
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EDP Sciences
2020-01-01
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| Online Access: | https://www.parasite-journal.org/articles/parasite/full_html/2020/01/parasite190127/parasite190127.html |
| _version_ | 1797421478642188288 |
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| author | Ahmadpour Ehsan Safarpour Hanie Xiao Lihua Zarean Mehdi Hatam-Nahavandi Kareem Barac Aleksandra Picot Stephane Rahimi Mohammad Taghi Rubino Salvatore Mahami-Oskouei Mahmoud Spotin Adel Nami Sanam Baghi Hossein Bannazadeh |
| author_facet | Ahmadpour Ehsan Safarpour Hanie Xiao Lihua Zarean Mehdi Hatam-Nahavandi Kareem Barac Aleksandra Picot Stephane Rahimi Mohammad Taghi Rubino Salvatore Mahami-Oskouei Mahmoud Spotin Adel Nami Sanam Baghi Hossein Bannazadeh |
| author_sort | Ahmadpour Ehsan |
| collection | DOAJ |
| description | Cryptosporidium is one of the major causes of diarrhea in HIV-positive patients. The aim of this study is to systematically review and meta-analyze the prevalence of Cryptosporidium in these patients. PubMed, Science Direct, Google Scholar, Web of Science, Cochrane and Ovid databases were searched for relevant studies dating from the period of 1 January 2000 to 31 December 2017. Data extraction for the included studies was performed independently by two authors. The overall pooled prevalence was calculated and subgroup analysis was performed on diagnostic methods, geographical distribution and study population. Meta-regression was performed on the year of publication, proportion of patients with diarrhea, and proportion of patients with CD4 < 200 cells/mL. One hundred and sixty-one studies and 51,123 HIV-positive participants were included. The overall pooled prevalence of Cryptosporidium infection in HIV-positive patients was 11.2% (CI95%: 9.4%–13.0%). The pooled prevalence was estimated to be 10.0% (CI95%: 8.4%–11.8%) using staining methods, 13.5% (CI95%: 8.9%–19.8%) using molecular methods, and 26.3% (CI95%: 15.0%–42.0%) using antigen detection methods. The prevalence of Cryptosporidium in HIV patients was significantly associated with the country of study. Also, there were statistical differences between the diarrhea, CD4 < 200 cells/mL, and antiretroviral therapy risk factors with Cryptosporidiosis. Thus, Cryptosporidium is a common infection in HIV-positive patients, and safe water and hand-hygiene should be implemented to prevent cryptosporidiosis occurrence in these patients. |
| first_indexed | 2024-03-09T07:18:04Z |
| format | Article |
| id | doaj.art-9cd69b48e22b4df18fa884018b9e4f47 |
| institution | Directory Open Access Journal |
| issn | 1776-1042 |
| language | English |
| last_indexed | 2024-03-09T07:18:04Z |
| publishDate | 2020-01-01 |
| publisher | EDP Sciences |
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| spelling | doaj.art-9cd69b48e22b4df18fa884018b9e4f472023-12-03T08:16:51ZengEDP SciencesParasite1776-10422020-01-01272710.1051/parasite/2020025parasite190127Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysisAhmadpour EhsanSafarpour Hanie0https://orcid.org/0000-0002-9622-2278Xiao Lihua1Zarean Mehdi2Hatam-Nahavandi Kareem3Barac Aleksandra4https://orcid.org/0000-0002-0132-2277Picot Stephane5https://orcid.org/0000-0002-5735-6759Rahimi Mohammad Taghi6Rubino Salvatore7Mahami-Oskouei Mahmoud8https://orcid.org/0000-0001-5169-5429Spotin Adel9Nami Sanam10https://orcid.org/0000-0001-9187-5555Baghi Hossein Bannazadeh11https://orcid.org/0000-0002-2513-5361Student Research Committee, Tabriz University of Medical SciencesCollege of Veterinary Medicine, South China Agricultural UniversityDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical SciencesIranshahr University of Medical SciencesClinic for Infectious and Tropical Diseases, Clinical Centre of SerbiaUniversity Lyon, ICBMS UMR 5246 CNRS-INSA-CPE & Institute of Parasitology and Medical Mycology, Croix-Rousse Hospital, Hospices Civils de LyonCenter for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical SciencesDepartment of Biomedical Sciences, University of SassariDepartment of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesDrug Applied Research Center, Tabriz University of Medical SciencesInfectious and Tropical Diseases Research Center, Tabriz University of Medical SciencesCryptosporidium is one of the major causes of diarrhea in HIV-positive patients. The aim of this study is to systematically review and meta-analyze the prevalence of Cryptosporidium in these patients. PubMed, Science Direct, Google Scholar, Web of Science, Cochrane and Ovid databases were searched for relevant studies dating from the period of 1 January 2000 to 31 December 2017. Data extraction for the included studies was performed independently by two authors. The overall pooled prevalence was calculated and subgroup analysis was performed on diagnostic methods, geographical distribution and study population. Meta-regression was performed on the year of publication, proportion of patients with diarrhea, and proportion of patients with CD4 < 200 cells/mL. One hundred and sixty-one studies and 51,123 HIV-positive participants were included. The overall pooled prevalence of Cryptosporidium infection in HIV-positive patients was 11.2% (CI95%: 9.4%–13.0%). The pooled prevalence was estimated to be 10.0% (CI95%: 8.4%–11.8%) using staining methods, 13.5% (CI95%: 8.9%–19.8%) using molecular methods, and 26.3% (CI95%: 15.0%–42.0%) using antigen detection methods. The prevalence of Cryptosporidium in HIV patients was significantly associated with the country of study. Also, there were statistical differences between the diarrhea, CD4 < 200 cells/mL, and antiretroviral therapy risk factors with Cryptosporidiosis. Thus, Cryptosporidium is a common infection in HIV-positive patients, and safe water and hand-hygiene should be implemented to prevent cryptosporidiosis occurrence in these patients.https://www.parasite-journal.org/articles/parasite/full_html/2020/01/parasite190127/parasite190127.htmlcryptosporidium infectionhivaidssystematic review |
| spellingShingle | Ahmadpour Ehsan Safarpour Hanie Xiao Lihua Zarean Mehdi Hatam-Nahavandi Kareem Barac Aleksandra Picot Stephane Rahimi Mohammad Taghi Rubino Salvatore Mahami-Oskouei Mahmoud Spotin Adel Nami Sanam Baghi Hossein Bannazadeh Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis Parasite cryptosporidium infection hiv aids systematic review |
| title | Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis |
| title_full | Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis |
| title_fullStr | Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis |
| title_full_unstemmed | Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis |
| title_short | Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis |
| title_sort | cryptosporidiosis in hiv positive patients and related risk factors a systematic review and meta analysis |
| topic | cryptosporidium infection hiv aids systematic review |
| url | https://www.parasite-journal.org/articles/parasite/full_html/2020/01/parasite190127/parasite190127.html |
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