Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p

Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p

Preliminary studies have shown that endothelial-monocyte-activating polypeptide-II (EMAP-II) and temozolomide (TMZ) alone can exert cytotoxic effects on glioma cells. This study explored whether EMAP-II can enhance the cytotoxic effects of TMZ on glioma stem cells (GSCs) and the possible mechanisms...

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Bibliographic Details
Main Authors: Jian Zhang, Libo Liu, Yixue Xue, Yawen Ma, Xiaobai Liu, Zhen Li, Zhiqing Li, Yunhui Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GSCs
EMAP-II
TMZ
BNIP3
mitophagy
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00092/full

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