Have you tried turning it off and on again? Oscillating selection to enhance fitness-landscape traversal in adaptive laboratory evolution experiments

Have you tried turning it off and on again? Oscillating selection to enhance fitness-landscape traversal in adaptive laboratory evolution experiments

Adaptive Laboratory Evolution (ALE) is a powerful tool for engineering and understanding microbial physiology. ALE relies on the selection and enrichment of mutations that enable survival or faster growth under a selective condition imposed by the experimental setup. Phenotypic fitness landscapes ar...

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Bibliographic Details
Main Authors:	Alexander C. Carpenter, Adam M. Feist, Fergus S.M. Harrison, Ian T. Paulsen, Thomas C. Williams
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Series:	Metabolic Engineering Communications
Online Access:	http://www.sciencedirect.com/science/article/pii/S221403012300010X

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