Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor
Tumor targeting drug delivery is of significant importance for the treatment of triple negative breast cancer (TNBC) considering the presence of appreciable amount of tumor matrix and the absence of effective targets on the tumor cells. Hence in this study, a new therapeutic multifunctional nanoplat...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037023001769 |
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| author | Lianfu Wang Manxiang Wu Yuning Pan Dong Xie Chengyuan Hong Jianbin Li Xuehua Ma Huachun Xu Huayu Li Tianxiang Chen Aiguo Wu Qiang Li |
| author_facet | Lianfu Wang Manxiang Wu Yuning Pan Dong Xie Chengyuan Hong Jianbin Li Xuehua Ma Huachun Xu Huayu Li Tianxiang Chen Aiguo Wu Qiang Li |
| author_sort | Lianfu Wang |
| collection | DOAJ |
| description | Tumor targeting drug delivery is of significant importance for the treatment of triple negative breast cancer (TNBC) considering the presence of appreciable amount of tumor matrix and the absence of effective targets on the tumor cells. Hence in this study, a new therapeutic multifunctional nanoplatform with improved TNBC targeting ability and efficacy was constructed and used for therapy of TNBC. Specifically, curcumin loaded mesoporous polydopamine (mPDA/Cur) nanoparticles were synthesized. Thereafter, manganese dioxide (MnO2) and a hybrid of cancer-associated fibroblasts (CAFs) membranes as well as cancer cell membranes were sequentially coated on the surface of mPDA/Cur to obtain mPDA/Cur@M/CM. It was found that two distinct kinds of cell membranes were able to endow the nano platform with homologous targeting ability, thereby achieving accurate delivery of drugs. Nanoparticles gathered in the tumor matrix can loosen the tumor matrix via the photothermal effect mediated by mPDA to rupture the physical barrier of tumor, which is conducive to the penetration and targeting of drugs to tumor cells in the deep tissues. Moreover, the existence of curcumin, MnO2 and mPDA was able to promote the apoptosis of cancer cells by promoting increased cytotoxicity, enhanced Fenton-like reaction, and thermal damage, respectively. Overall, both in vitro and in vivo results showed that the designed biomimetic nanoplatform could significantly inhibit the tumor growth and thus provide an efficient novel therapeutic strategy for TNBC. |
| first_indexed | 2024-03-08T21:30:19Z |
| format | Article |
| id | doaj.art-9cdb700a79b04299aef802cc75b2fd4d |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:30:19Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-9cdb700a79b04299aef802cc75b2fd4d2023-12-21T07:31:28ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-012127802791Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumorLianfu Wang0Manxiang Wu1Yuning Pan2Dong Xie3Chengyuan Hong4Jianbin Li5Xuehua Ma6Huachun Xu7Huayu Li8Tianxiang Chen9Aiguo Wu10Qiang Li11Department of Radiology, The Affiliated People’s Hospital, Ningbo University, Ningbo 315040, China; Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, ChinaDepartment of Radiology, The Affiliated People’s Hospital, Ningbo University, Ningbo 315040, China; Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, ChinaDepartment of Radiology, The Affiliated People’s Hospital, Ningbo University, Ningbo 315040, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China; Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham Ningbo China, Ningbo 315100, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, ChinaDepartment of Radiology, The Affiliated People’s Hospital, Ningbo University, Ningbo 315040, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, ChinaDepartment of Radiology, The Affiliated People’s Hospital, Ningbo University, Ningbo 315040, ChinaDepartment of Radiology, The Affiliated People’s Hospital, Ningbo University, Ningbo 315040, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, China; Corresponding authors at: Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China.Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, China; Corresponding authors at: Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, China.Department of Radiology, The Affiliated People’s Hospital, Ningbo University, Ningbo 315040, China; Corresponding author.Tumor targeting drug delivery is of significant importance for the treatment of triple negative breast cancer (TNBC) considering the presence of appreciable amount of tumor matrix and the absence of effective targets on the tumor cells. Hence in this study, a new therapeutic multifunctional nanoplatform with improved TNBC targeting ability and efficacy was constructed and used for therapy of TNBC. Specifically, curcumin loaded mesoporous polydopamine (mPDA/Cur) nanoparticles were synthesized. Thereafter, manganese dioxide (MnO2) and a hybrid of cancer-associated fibroblasts (CAFs) membranes as well as cancer cell membranes were sequentially coated on the surface of mPDA/Cur to obtain mPDA/Cur@M/CM. It was found that two distinct kinds of cell membranes were able to endow the nano platform with homologous targeting ability, thereby achieving accurate delivery of drugs. Nanoparticles gathered in the tumor matrix can loosen the tumor matrix via the photothermal effect mediated by mPDA to rupture the physical barrier of tumor, which is conducive to the penetration and targeting of drugs to tumor cells in the deep tissues. Moreover, the existence of curcumin, MnO2 and mPDA was able to promote the apoptosis of cancer cells by promoting increased cytotoxicity, enhanced Fenton-like reaction, and thermal damage, respectively. Overall, both in vitro and in vivo results showed that the designed biomimetic nanoplatform could significantly inhibit the tumor growth and thus provide an efficient novel therapeutic strategy for TNBC.http://www.sciencedirect.com/science/article/pii/S2001037023001769Triple negative breast cancerCell membranesPhotothermal therapyChemotherapyPolydopamine |
| spellingShingle | Lianfu Wang Manxiang Wu Yuning Pan Dong Xie Chengyuan Hong Jianbin Li Xuehua Ma Huachun Xu Huayu Li Tianxiang Chen Aiguo Wu Qiang Li Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor Computational and Structural Biotechnology Journal Triple negative breast cancer Cell membranes Photothermal therapy Chemotherapy Polydopamine |
| title | Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor |
| title_full | Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor |
| title_fullStr | Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor |
| title_full_unstemmed | Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor |
| title_short | Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor |
| title_sort | sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor |
| topic | Triple negative breast cancer Cell membranes Photothermal therapy Chemotherapy Polydopamine |
| url | http://www.sciencedirect.com/science/article/pii/S2001037023001769 |
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