Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast
Overweight and obesity prevalence has increased worldwide. Apart from conventional approaches, people also resort to botanical supplements for reducing body weight, although several adverse events have been associated with these products. In this context, the present study aimed at evaluating the to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/9/1771 |
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| author | Silvia Di Giacomo Antonella Di Sotto Ester Percaccio Erica Scuotto Cecilia Battistelli Gabriela Mazzanti Francesca Menniti-Ippolito Ilaria Ippoliti |
| author_facet | Silvia Di Giacomo Antonella Di Sotto Ester Percaccio Erica Scuotto Cecilia Battistelli Gabriela Mazzanti Francesca Menniti-Ippolito Ilaria Ippoliti |
| author_sort | Silvia Di Giacomo |
| collection | DOAJ |
| description | Overweight and obesity prevalence has increased worldwide. Apart from conventional approaches, people also resort to botanical supplements for reducing body weight, although several adverse events have been associated with these products. In this context, the present study aimed at evaluating the toxicity of <i>Garcinia cambogia</i>-based products and shedding light on the mechanisms involved. The suspected hepatotoxic reactions related to <i>G. cambogia</i>-containing products collected within the Italian Phytovigilance System (IPS) were examined. Then, an in vitro study was performed to evaluate the possible mechanisms responsible for the liver toxicity, focusing on the modulation of oxidative stress and Nrf2 expression. From March 2002 to March 2022, the IPS collected eight reports of hepatic adverse reactions related to <i>G. cambogia</i>, which exclusively involved women and were mostly severe. The causality assessment was probable in three cases, while it was possible in five. In the in vitro experiments, a low cytotoxicity of <i>G. cambogia</i> was observed. However, its combination with montelukast greatly reduced cell viability, increased the intracellular ROS levels, and affected the cytoplasmic Nrf2 expression, thus suggesting an impairment of the antioxidant and cytoprotective defenses. Overall, our results support the safety concerns about <i>G. cambogia</i>-containing supplements and shed light on the possible mechanisms underpinning its hepatotoxicity. |
| first_indexed | 2024-03-10T23:05:41Z |
| format | Article |
| id | doaj.art-9ce08f35c1d64095872c1a1e51c50b5c |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T23:05:41Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-9ce08f35c1d64095872c1a1e51c50b5c2023-11-19T09:20:13ZengMDPI AGAntioxidants2076-39212023-09-01129177110.3390/antiox12091771Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of MontelukastSilvia Di Giacomo0Antonella Di Sotto1Ester Percaccio2Erica Scuotto3Cecilia Battistelli4Gabriela Mazzanti5Francesca Menniti-Ippolito6Ilaria Ippoliti7Department of Food Safety, Nutrition and Veterinary Public Health, National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyDepartment of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyNational Centre for Drug Research and Evaluation, National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyNational Centre for Drug Research and Evaluation, National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyOverweight and obesity prevalence has increased worldwide. Apart from conventional approaches, people also resort to botanical supplements for reducing body weight, although several adverse events have been associated with these products. In this context, the present study aimed at evaluating the toxicity of <i>Garcinia cambogia</i>-based products and shedding light on the mechanisms involved. The suspected hepatotoxic reactions related to <i>G. cambogia</i>-containing products collected within the Italian Phytovigilance System (IPS) were examined. Then, an in vitro study was performed to evaluate the possible mechanisms responsible for the liver toxicity, focusing on the modulation of oxidative stress and Nrf2 expression. From March 2002 to March 2022, the IPS collected eight reports of hepatic adverse reactions related to <i>G. cambogia</i>, which exclusively involved women and were mostly severe. The causality assessment was probable in three cases, while it was possible in five. In the in vitro experiments, a low cytotoxicity of <i>G. cambogia</i> was observed. However, its combination with montelukast greatly reduced cell viability, increased the intracellular ROS levels, and affected the cytoplasmic Nrf2 expression, thus suggesting an impairment of the antioxidant and cytoprotective defenses. Overall, our results support the safety concerns about <i>G. cambogia</i>-containing supplements and shed light on the possible mechanisms underpinning its hepatotoxicity.https://www.mdpi.com/2076-3921/12/9/1771<i>Garcinia cambogia</i>herb-induced liver injuryphytovigilanceherb-drug interactionssynergismoxidative stress |
| spellingShingle | Silvia Di Giacomo Antonella Di Sotto Ester Percaccio Erica Scuotto Cecilia Battistelli Gabriela Mazzanti Francesca Menniti-Ippolito Ilaria Ippoliti Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast Antioxidants <i>Garcinia cambogia</i> herb-induced liver injury phytovigilance herb-drug interactions synergism oxidative stress |
| title | Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast |
| title_full | Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast |
| title_fullStr | Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast |
| title_full_unstemmed | Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast |
| title_short | Interaction of <i>Garcinia cambogia</i> (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast |
| title_sort | interaction of i garcinia cambogia i gaertn desr and drugs as a possible mechanism of liver injury the case of montelukast |
| topic | <i>Garcinia cambogia</i> herb-induced liver injury phytovigilance herb-drug interactions synergism oxidative stress |
| url | https://www.mdpi.com/2076-3921/12/9/1771 |
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