The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic review
Abstract Background In the pediatric oncology population, oral mucositis as a consequence of chemotherapy is a highly prevalent complication which strongly affects both the quality of life and treatment possibilities of the patients. Still, the etiopathological mechanisms carrying to its development...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-024-03938-y |
| _version_ | 1827325971016974336 |
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| author | Pierfrancesco Filetici Sofia Germana Gallottini Andrea Corvaglia Martina Amendolea Roberta Sangiovanni Fabrizio Nicoletti Antonio D’Addona Leonardo Dassatti |
| author_facet | Pierfrancesco Filetici Sofia Germana Gallottini Andrea Corvaglia Martina Amendolea Roberta Sangiovanni Fabrizio Nicoletti Antonio D’Addona Leonardo Dassatti |
| author_sort | Pierfrancesco Filetici |
| collection | DOAJ |
| description | Abstract Background In the pediatric oncology population, oral mucositis as a consequence of chemotherapy is a highly prevalent complication which strongly affects both the quality of life and treatment possibilities of the patients. Still, the etiopathological mechanisms carrying to its development are not fully understood, although a possible role of oral dysbiosis has been previously investigated with unclear conclusions. The aim of this systematic review was to assess the available evidence on the role of microbiota in the development of oral mucositis. Methods A systematic literature search was performed following PRISMA guidelines. Three electronic databases were searched up until April 2023 and a following manual search included the reference lists of the included studies and reviews. Studies reporting microbiological and clinical data of pediatric patients treated by antineoplastic drugs were included. Results Thirteen studies met the inclusion criteria, reporting an average mucositis prevalence of 57,6%. Candida albicans infections were frequently observed in studies performing microbiological analysis on oral lesions, in contrast with the low rate detection of the Herpes simplex viruses. Bacterial species such as coagulase-negative Staphylococci and Streptococcus viridans were detected more frequently on lesion sites. Studies reporting a quantitative analysis of the general flora did not show comparable results. Risk of bias assessment among studies was generally considered high or very high. Conclusions While the specific role of certain microbiological agents, such as Candida albicans, was frequently reported among studies, data regarding the general dynamics of oral microbiota in the development of oral mucositis are lacking in the current literature. Thus, more studies are needed to provide the knowledge required in order to improve protocols for the prevention and treatment of this threatening complication. |
| first_indexed | 2024-03-07T14:37:57Z |
| format | Article |
| id | doaj.art-9ce20c0dbbac49ea9113dd30b81596cf |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-07T14:37:57Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-9ce20c0dbbac49ea9113dd30b81596cf2024-03-05T20:34:28ZengBMCBMC Oral Health1472-68312024-02-0124111910.1186/s12903-024-03938-yThe role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic reviewPierfrancesco Filetici0Sofia Germana Gallottini1Andrea Corvaglia2Martina Amendolea3Roberta Sangiovanni4Fabrizio Nicoletti5Antonio D’Addona6Leonardo Dassatti7Department of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreDepartment of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreDepartment of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreDepartment of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreDepartment of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreDepartment of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreDepartment of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreDepartment of Head and Neck and Sensory Organs, Università Cattolica del Sacro CuoreAbstract Background In the pediatric oncology population, oral mucositis as a consequence of chemotherapy is a highly prevalent complication which strongly affects both the quality of life and treatment possibilities of the patients. Still, the etiopathological mechanisms carrying to its development are not fully understood, although a possible role of oral dysbiosis has been previously investigated with unclear conclusions. The aim of this systematic review was to assess the available evidence on the role of microbiota in the development of oral mucositis. Methods A systematic literature search was performed following PRISMA guidelines. Three electronic databases were searched up until April 2023 and a following manual search included the reference lists of the included studies and reviews. Studies reporting microbiological and clinical data of pediatric patients treated by antineoplastic drugs were included. Results Thirteen studies met the inclusion criteria, reporting an average mucositis prevalence of 57,6%. Candida albicans infections were frequently observed in studies performing microbiological analysis on oral lesions, in contrast with the low rate detection of the Herpes simplex viruses. Bacterial species such as coagulase-negative Staphylococci and Streptococcus viridans were detected more frequently on lesion sites. Studies reporting a quantitative analysis of the general flora did not show comparable results. Risk of bias assessment among studies was generally considered high or very high. Conclusions While the specific role of certain microbiological agents, such as Candida albicans, was frequently reported among studies, data regarding the general dynamics of oral microbiota in the development of oral mucositis are lacking in the current literature. Thus, more studies are needed to provide the knowledge required in order to improve protocols for the prevention and treatment of this threatening complication.https://doi.org/10.1186/s12903-024-03938-yPediatricsNeoplasmsChemotherapyOral mucositisMicrobiota |
| spellingShingle | Pierfrancesco Filetici Sofia Germana Gallottini Andrea Corvaglia Martina Amendolea Roberta Sangiovanni Fabrizio Nicoletti Antonio D’Addona Leonardo Dassatti The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic review BMC Oral Health Pediatrics Neoplasms Chemotherapy Oral mucositis Microbiota |
| title | The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic review |
| title_full | The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic review |
| title_fullStr | The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic review |
| title_full_unstemmed | The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic review |
| title_short | The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: a systematic review |
| title_sort | role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs a systematic review |
| topic | Pediatrics Neoplasms Chemotherapy Oral mucositis Microbiota |
| url | https://doi.org/10.1186/s12903-024-03938-y |
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