Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis
Objective: Irreversible electroporation (IRE) is a novel nonthermal ablative technique that transmits pulsatile electricity to enable nanoscale damages of the cellular membrane and induce cellular apoptosis. To assess the safety and efficacy of IRE for locally advanced pancreatic cancer (LAPC). Meth...
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| Format: | Article |
| Language: | English |
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Editorial Office of Advanced Ultrasound in Diagnosis and Therapy
2018-08-01
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| Series: | Advanced Ultrasound in Diagnosis and Therapy |
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| Online Access: | http://www.journaladvancedultrasound.com:81/fileup/2576-2516/PDF/1534732219493-669641266.pdf |
| _version_ | 1819068897151680512 |
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| author | Tian’an Jiang, PhD, Guo Tian, MD, Liming Wu, PhD, Qiyu Zhao, PhD |
| author_facet | Tian’an Jiang, PhD, Guo Tian, MD, Liming Wu, PhD, Qiyu Zhao, PhD |
| author_sort | Tian’an Jiang, PhD, Guo Tian, MD, Liming Wu, PhD, Qiyu Zhao, PhD |
| collection | DOAJ |
| description | Objective: Irreversible electroporation (IRE) is a novel nonthermal ablative technique that transmits pulsatile electricity to enable nanoscale damages of the cellular membrane and induce cellular apoptosis. To assess the safety and efficacy of IRE for locally advanced pancreatic cancer (LAPC). Methods: Electronic databases of PubMed, Embase, Web of Science, Scopus were searched up to June 2018 for studies comparing the standardized mean differences (SMD) of size, amylase and carbohydrate antigen 19-9 (CA199) levels between pre- and post-operation for patients with pancreatic cancer. Sensitivity and stratified analyses were conducted. Quality was estimated using Newcastle-Ottawa Scale (NOS). Results: We finally identified 10 studies including 203 participants during a mean 7.06 months of follow-up (range 1 to 29 months). The meta-analyses showed the declined tumor size at 6 months post-IRE but unchanged at 1 month, and increased amylase level at 1-day post-IRE while unchanged at the 1 week. No significant difference of CA199 level was observed between pre-IRE and post-IRE at 1 week and 1 month. No risk of publication bias was detectable, and the favorable quality and validity of all outcomes were assessed based on NOS. Conclusions: IRE may be a relatively state-of-the-art therapy option for most patients with LAPC if imaging or explorative laparotomy indicated that LAPC was unable to be successfully resected. |
| first_indexed | 2024-12-21T16:41:26Z |
| format | Article |
| id | doaj.art-9ce2f31e1dcc442a98dba4e14d0c16e7 |
| institution | Directory Open Access Journal |
| issn | 2576-2516 |
| language | English |
| last_indexed | 2024-12-21T16:41:26Z |
| publishDate | 2018-08-01 |
| publisher | Editorial Office of Advanced Ultrasound in Diagnosis and Therapy |
| record_format | Article |
| series | Advanced Ultrasound in Diagnosis and Therapy |
| spelling | doaj.art-9ce2f31e1dcc442a98dba4e14d0c16e72022-12-21T18:57:06ZengEditorial Office of Advanced Ultrasound in Diagnosis and TherapyAdvanced Ultrasound in Diagnosis and Therapy2576-25162018-08-012214314910.37015/AUDT.2018.180814Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysisTian’an Jiang, PhD, Guo Tian, MD, Liming Wu, PhD, Qiyu Zhao, PhD0a Department of Ultrasound Medicine, the First Afliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;b Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China;c Department of Hepatobiliary and Pancreatic Surgery, the First Afliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;d Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaObjective: Irreversible electroporation (IRE) is a novel nonthermal ablative technique that transmits pulsatile electricity to enable nanoscale damages of the cellular membrane and induce cellular apoptosis. To assess the safety and efficacy of IRE for locally advanced pancreatic cancer (LAPC). Methods: Electronic databases of PubMed, Embase, Web of Science, Scopus were searched up to June 2018 for studies comparing the standardized mean differences (SMD) of size, amylase and carbohydrate antigen 19-9 (CA199) levels between pre- and post-operation for patients with pancreatic cancer. Sensitivity and stratified analyses were conducted. Quality was estimated using Newcastle-Ottawa Scale (NOS). Results: We finally identified 10 studies including 203 participants during a mean 7.06 months of follow-up (range 1 to 29 months). The meta-analyses showed the declined tumor size at 6 months post-IRE but unchanged at 1 month, and increased amylase level at 1-day post-IRE while unchanged at the 1 week. No significant difference of CA199 level was observed between pre-IRE and post-IRE at 1 week and 1 month. No risk of publication bias was detectable, and the favorable quality and validity of all outcomes were assessed based on NOS. Conclusions: IRE may be a relatively state-of-the-art therapy option for most patients with LAPC if imaging or explorative laparotomy indicated that LAPC was unable to be successfully resected.http://www.journaladvancedultrasound.com:81/fileup/2576-2516/PDF/1534732219493-669641266.pdf|irreversible electroporation|pancreatic cancer|meta|systematic review|outcome |
| spellingShingle | Tian’an Jiang, PhD, Guo Tian, MD, Liming Wu, PhD, Qiyu Zhao, PhD Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis Advanced Ultrasound in Diagnosis and Therapy |irreversible electroporation|pancreatic cancer|meta|systematic review|outcome |
| title | Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis |
| title_full | Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis |
| title_fullStr | Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis |
| title_short | Estimation of Clinical Outcomes of Irreversible Electroporation Use During Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis |
| title_sort | estimation of clinical outcomes of irreversible electroporation use during locally advanced pancreatic cancer a systematic review and meta analysis |
| topic | |irreversible electroporation|pancreatic cancer|meta|systematic review|outcome |
| url | http://www.journaladvancedultrasound.com:81/fileup/2576-2516/PDF/1534732219493-669641266.pdf |
| work_keys_str_mv | AT tiananjiangphdguotianmdlimingwuphdqiyuzhaophd estimationofclinicaloutcomesofirreversibleelectroporationuseduringlocallyadvancedpancreaticcancerasystematicreviewandmetaanalysis |