Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy
Immunotherapy holds great promise in cancer treatment. The challenges in advancing immunotherapies lie in patient stratification and monitoring therapy. Noninvasive detection of immune checkpoint ligand PD-L1 can serve as an important biomarker for guidance and monitoring of immunotherapy. Here in,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2017-07-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117718459 |
| _version_ | 1797288852397752320 |
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| author | Samit Chatterjee PhD Wojciech G. Lesniak PhD Sridhar Nimmagadda PhD |
| author_facet | Samit Chatterjee PhD Wojciech G. Lesniak PhD Sridhar Nimmagadda PhD |
| author_sort | Samit Chatterjee PhD |
| collection | DOAJ |
| description | Immunotherapy holds great promise in cancer treatment. The challenges in advancing immunotherapies lie in patient stratification and monitoring therapy. Noninvasive detection of immune checkpoint ligand PD-L1 can serve as an important biomarker for guidance and monitoring of immunotherapy. Here in, we provide an overview of our efforts to develop clinically translatable PD-L1-specific imaging agents for quantitative and real-time assessment of PD-L1 expression in tumor microenvironment. |
| first_indexed | 2024-03-07T18:55:35Z |
| format | Article |
| id | doaj.art-9ce32b6c86bc446b8bc84d0088d6d2a4 |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2024-03-07T18:55:35Z |
| publishDate | 2017-07-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-9ce32b6c86bc446b8bc84d0088d6d2a42024-03-02T00:26:01ZengSAGE PublicationsMolecular Imaging1536-01212017-07-011610.1177/1536012117718459Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding ImmunotherapySamit Chatterjee PhD0Wojciech G. Lesniak PhD1Sridhar Nimmagadda PhD2 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD, USA Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD, USA Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USAImmunotherapy holds great promise in cancer treatment. The challenges in advancing immunotherapies lie in patient stratification and monitoring therapy. Noninvasive detection of immune checkpoint ligand PD-L1 can serve as an important biomarker for guidance and monitoring of immunotherapy. Here in, we provide an overview of our efforts to develop clinically translatable PD-L1-specific imaging agents for quantitative and real-time assessment of PD-L1 expression in tumor microenvironment.https://doi.org/10.1177/1536012117718459 |
| spellingShingle | Samit Chatterjee PhD Wojciech G. Lesniak PhD Sridhar Nimmagadda PhD Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy Molecular Imaging |
| title | Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy |
| title_full | Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy |
| title_fullStr | Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy |
| title_full_unstemmed | Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy |
| title_short | Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy |
| title_sort | noninvasive imaging of immune checkpoint ligand pd l1 in tumors and metastases for guiding immunotherapy |
| url | https://doi.org/10.1177/1536012117718459 |
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