Pharmacodynamics and Outcomes of a De-Escalation Strategy with Half-Dose Prasugrel or Ticagrelor in East Asians Patients with Acute Coronary Syndrome: Results from HOPE-TAILOR Trial

Pharmacodynamics and Outcomes of a De-Escalation Strategy with Half-Dose Prasugrel or Ticagrelor in East Asians Patients with Acute Coronary Syndrome: Results from HOPE-TAILOR Trial

East Asians treated with potent P2Y12 inhibitors (prasugrel or ticagrelor) generally experience more intense platelet inhibitory responses resulting in an increased risk of major bleeding. Whether a half-dose de-escalation strategy improves the net clinical benefit in Korean patients with acute coro...

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Bibliographic Details
Main Authors: Cai-De Jin, Moo-Hyun Kim, Kai Song, Xuan Jin, Kwang-Min Lee, Jong-Sung Park, Young-Rak Cho, Sung-Cheol Yun, Michael S. Lee
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Journal of Clinical Medicine
Subjects:
half-dose reduction
prasugrel
ticagrelor
pharmacodynamics
outcomes
acute coronary syndrome
Online Access:https://www.mdpi.com/2077-0383/10/12/2699

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