Baseline platelet count may predict short-term functional outcome of cerebral infarction
Abstract Background and aims Platelets play an important role in homeostasis however, they have also been associated with increased mortality after myocardial infarction. In the present study, we investigated whether platelet count is associated with differences in the short-term prognosis at the ti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-022-02845-5 |
| _version_ | 1811285883826995200 |
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| author | Kazo Kanazawa Nobukazu Miyamoto Kenichiro Hira Chikage Kijima Yuji Ueno Nobutaka Hattori |
| author_facet | Kazo Kanazawa Nobukazu Miyamoto Kenichiro Hira Chikage Kijima Yuji Ueno Nobutaka Hattori |
| author_sort | Kazo Kanazawa |
| collection | DOAJ |
| description | Abstract Background and aims Platelets play an important role in homeostasis however, they have also been associated with increased mortality after myocardial infarction. In the present study, we investigated whether platelet count is associated with differences in the short-term prognosis at the time of hospital discharge and early neurological deterioration in ischemic stroke patients. Methods Patients with ischemic stroke were enrolled from among 661 cerebrovascular disease patients admitted between January 2018 and December 2020. Patients who received hyperacute treatment, had a pre-onset modified Rankin scale (mRS) ≥ 3, transient ischemic attack, or active malignant disease were excluded. The platelet count was divided into quartiles (Q1-4) according to the number of patients, and the relationship between platelet count and prognosis was assessed using multivariable analysis. Results In total, 385 patients were included in the study. Regarding the functional outcome by platelet count, there was a significant increase in mRS ≥ 3 at discharge in the Q4 (range: 243–1327 × 109/L, p = 0.013, ORs: 1.674, 95%CI: 1.253–6.681) group compared to the Q3 (range: 205–242 × 109/L) group even after adjusting for factors with P < 0.2 in univariate analysis. Furthermore, the frequency of neurological deterioration (NIHSS ≥ 4) within 1 week was significantly lower in the Q3 group than in the Q1 (range; 19–173 × 109/L) and Q4 groups even after adjustment (Q1; p = 0.020 ORs: 6.634, 95%CI: 1.352–32.557, Q4; p = 0.007 ORs: 8.765, 95%CI: 1.827–42.035). Conclusion Platelet count at onset may affect the prognosis of cerebral infarction and early neurological deterioration. This study may help clarify the pathogenesis of cerebral infarction to improve prognosis. |
| first_indexed | 2024-04-13T02:51:26Z |
| format | Article |
| id | doaj.art-9ce4cdde49e64cbbba18adf546b04c08 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-13T02:51:26Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-9ce4cdde49e64cbbba18adf546b04c082022-12-22T03:05:50ZengBMCBMC Neurology1471-23772022-08-012211810.1186/s12883-022-02845-5Baseline platelet count may predict short-term functional outcome of cerebral infarctionKazo Kanazawa0Nobukazu Miyamoto1Kenichiro Hira2Chikage Kijima3Yuji Ueno4Nobutaka Hattori5Department of Neurology, Juntendo University School of MedicineDepartment of Neurology, Juntendo University School of MedicineDepartment of Neurology, Juntendo University School of MedicineDepartment of Neurology, Juntendo University School of MedicineDepartment of Neurology, Juntendo University School of MedicineDepartment of Neurology, Juntendo University School of MedicineAbstract Background and aims Platelets play an important role in homeostasis however, they have also been associated with increased mortality after myocardial infarction. In the present study, we investigated whether platelet count is associated with differences in the short-term prognosis at the time of hospital discharge and early neurological deterioration in ischemic stroke patients. Methods Patients with ischemic stroke were enrolled from among 661 cerebrovascular disease patients admitted between January 2018 and December 2020. Patients who received hyperacute treatment, had a pre-onset modified Rankin scale (mRS) ≥ 3, transient ischemic attack, or active malignant disease were excluded. The platelet count was divided into quartiles (Q1-4) according to the number of patients, and the relationship between platelet count and prognosis was assessed using multivariable analysis. Results In total, 385 patients were included in the study. Regarding the functional outcome by platelet count, there was a significant increase in mRS ≥ 3 at discharge in the Q4 (range: 243–1327 × 109/L, p = 0.013, ORs: 1.674, 95%CI: 1.253–6.681) group compared to the Q3 (range: 205–242 × 109/L) group even after adjusting for factors with P < 0.2 in univariate analysis. Furthermore, the frequency of neurological deterioration (NIHSS ≥ 4) within 1 week was significantly lower in the Q3 group than in the Q1 (range; 19–173 × 109/L) and Q4 groups even after adjustment (Q1; p = 0.020 ORs: 6.634, 95%CI: 1.352–32.557, Q4; p = 0.007 ORs: 8.765, 95%CI: 1.827–42.035). Conclusion Platelet count at onset may affect the prognosis of cerebral infarction and early neurological deterioration. This study may help clarify the pathogenesis of cerebral infarction to improve prognosis.https://doi.org/10.1186/s12883-022-02845-5Platelet countCerebral infarctionNeurological deteriorationEarly prognosisRisk factors |
| spellingShingle | Kazo Kanazawa Nobukazu Miyamoto Kenichiro Hira Chikage Kijima Yuji Ueno Nobutaka Hattori Baseline platelet count may predict short-term functional outcome of cerebral infarction BMC Neurology Platelet count Cerebral infarction Neurological deterioration Early prognosis Risk factors |
| title | Baseline platelet count may predict short-term functional outcome of cerebral infarction |
| title_full | Baseline platelet count may predict short-term functional outcome of cerebral infarction |
| title_fullStr | Baseline platelet count may predict short-term functional outcome of cerebral infarction |
| title_full_unstemmed | Baseline platelet count may predict short-term functional outcome of cerebral infarction |
| title_short | Baseline platelet count may predict short-term functional outcome of cerebral infarction |
| title_sort | baseline platelet count may predict short term functional outcome of cerebral infarction |
| topic | Platelet count Cerebral infarction Neurological deterioration Early prognosis Risk factors |
| url | https://doi.org/10.1186/s12883-022-02845-5 |
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