Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiated
Abstract Ergotioneine (ERG) has potential applications as food additive and as an antioxidant for the treatment and/or prevention of diseases related to oxidative stress. In this work, we study the nature of antioxidant activity and investigate the effect of aqueous extracts of Agaricus bisporus enr...
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| Format: | Article |
| Language: | Spanish |
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Knowledge E
2021-08-01
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| Series: | ESPOCH Congresses |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/espoch.v1i3.9533 |
| _version_ | 1797989182690295808 |
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| author | Anabell Del Rocío Urbina-Salazar Alberto Renato Inca-Torres Bryan Anthony Urbina-Salazar Valeria Fernanda Inca-Torres Juan Bautista |
| author_facet | Anabell Del Rocío Urbina-Salazar Alberto Renato Inca-Torres Bryan Anthony Urbina-Salazar Valeria Fernanda Inca-Torres Juan Bautista |
| author_sort | Anabell Del Rocío Urbina-Salazar |
| collection | DOAJ |
| description | Abstract Ergotioneine (ERG) has potential applications as food additive and as an antioxidant for the treatment and/or prevention of diseases related to oxidative stress. In this work, we study the nature of antioxidant activity and investigate the effect of aqueous extracts of Agaricus bisporus enriched with ergotioneine (EAHE-ERG), a natural product, obtained through enzymatic digestion and membrane technology, in cellular response induced by UV, in crops fibroblasts. EAHE-ERG suppressed by the increase of TNF-α by UV-B radiation. Furthermore, in fibroblasts exposed to UV-A, EAHE-ERG suppressed the expression of matrix metalloproteinase-1 protein (MMP-1) in almost 50% and reduced the RNAm expression from MMP-1. From these results, we conclude that EAHE-ERG can reduce anti-aging effects of the skin from UV radiation by removing O 2 and 1O 2 , and the reduction protease signs and inflammatory activity. |
| first_indexed | 2024-04-11T08:16:09Z |
| format | Article |
| id | doaj.art-9ce5dc30403e44968e368d4091b23bac |
| institution | Directory Open Access Journal |
| issn | 2789-5009 |
| language | Spanish |
| last_indexed | 2024-04-11T08:16:09Z |
| publishDate | 2021-08-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | ESPOCH Congresses |
| spelling | doaj.art-9ce5dc30403e44968e368d4091b23bac2022-12-22T04:35:09ZspaKnowledge EESPOCH Congresses2789-50092021-08-01111072108010.18502/espoch.v1i3.9533espoch.v1i3.9533Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiatedAnabell Del Rocío Urbina-Salazar0Alberto Renato Inca-Torres1Bryan Anthony Urbina-Salazar2Valeria Fernanda Inca-Torres3Juan Bautista4Universidad Técnica de Manabí, Instituto de Ciencias Básicas, Portoviejo, EcuadorUniversidad Técnica de Manabí, Instituto de Ciencias Básicas, Portoviejo, EcuadorUniversidad Técnica de Ambato, Facultad de Ciencias de la Salud, Carrera de Medicina, Ambato, EcuadorHospital Básico Baños, Baños, EcuadorUniversidad de Sevilla, Facultad de Farmacia, Departamento de Bioquímica y Biología Molecular, Sevilla, EspañaAbstract Ergotioneine (ERG) has potential applications as food additive and as an antioxidant for the treatment and/or prevention of diseases related to oxidative stress. In this work, we study the nature of antioxidant activity and investigate the effect of aqueous extracts of Agaricus bisporus enriched with ergotioneine (EAHE-ERG), a natural product, obtained through enzymatic digestion and membrane technology, in cellular response induced by UV, in crops fibroblasts. EAHE-ERG suppressed by the increase of TNF-α by UV-B radiation. Furthermore, in fibroblasts exposed to UV-A, EAHE-ERG suppressed the expression of matrix metalloproteinase-1 protein (MMP-1) in almost 50% and reduced the RNAm expression from MMP-1. From these results, we conclude that EAHE-ERG can reduce anti-aging effects of the skin from UV radiation by removing O 2 and 1O 2 , and the reduction protease signs and inflammatory activity.https://doi.org/10.18502/espoch.v1i3.9533ergotioneine, agaricus bisporus, antioxidant, nutraceutical, anti-inflammatory |
| spellingShingle | Anabell Del Rocío Urbina-Salazar Alberto Renato Inca-Torres Bryan Anthony Urbina-Salazar Valeria Fernanda Inca-Torres Juan Bautista Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiated ESPOCH Congresses ergotioneine, agaricus bisporus, antioxidant, nutraceutical, anti-inflammatory |
| title | Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiated |
| title_full | Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiated |
| title_fullStr | Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiated |
| title_full_unstemmed | Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiated |
| title_short | Aqueous Extracts of Mushrooms Enriched with Ergothionein with Antioxidant Activity and Its Effect on Human Dermal Fibroblasts UV irradiated |
| title_sort | aqueous extracts of mushrooms enriched with ergothionein with antioxidant activity and its effect on human dermal fibroblasts uv irradiated |
| topic | ergotioneine, agaricus bisporus, antioxidant, nutraceutical, anti-inflammatory |
| url | https://doi.org/10.18502/espoch.v1i3.9533 |
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