Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats
Honey is rich in bioactive compounds, phenolic acids, and flavonoids and is an antioxidant and an immunomodulator. The objectives of this study were to determine the honey chemical composition of Indonesian stingless bees and their potential roles as an immunomodulator in the malnourished rats. Tetr...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Saudi Journal of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X22003205 |
| _version_ | 1798000867029286912 |
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| author | Agussalim Nafiatul Umami Nurliyani Ali Agus |
| author_facet | Agussalim Nafiatul Umami Nurliyani Ali Agus |
| author_sort | Agussalim |
| collection | DOAJ |
| description | Honey is rich in bioactive compounds, phenolic acids, and flavonoids and is an antioxidant and an immunomodulator. The objectives of this study were to determine the honey chemical composition of Indonesian stingless bees and their potential roles as an immunomodulator in the malnourished rats. Tetragonula laeviceps honey was used to analyses of chemical composition was obtained from three different geographical origins were Depok Sleman, Bayan Lombok, and Nglipar Gunungkidul. Thirty-two rats were divided into four groups of 8 rats and placed in individual cages. The experimental designed was as follows: T1 = normal rats + without honey (0–7 weeks), T2 = normal rats + with honey of 1.8 g/kg BW/day (0–7 weeks), T3 = malnourished honey of 1.8 g/kg BW/day started from 2 weeks after the malnourished condition (2–7 weeks). The results showed that the chemical composition of Tetragonula laeviceps honey from three different geographical origins were vitamin C content (6.49–13.58 mg/100 g), total phenolic content (0.65–2.30% GAE/100 g), total flavonoid content (0.28–1.00 mg QE/g), and antioxidant activity DPPH (61.43–90.28%). The application of fresh honey from stingless bee that was offered to either normal or malnourished rats were increased lymphocytes proliferation and decreased the production of both proinflammatory markers, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) from tissue culture supernatant of lymphocytes (p < 0.01). Data from this study clearly indicates the potential role of honey from stingless bee as an immunomodulator in malnourished rats. |
| first_indexed | 2024-04-11T11:27:09Z |
| format | Article |
| id | doaj.art-9ce61f279cb94410a8f66944f644e888 |
| institution | Directory Open Access Journal |
| issn | 1319-562X |
| language | English |
| last_indexed | 2024-04-11T11:27:09Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Journal of Biological Sciences |
| spelling | doaj.art-9ce61f279cb94410a8f66944f644e8882022-12-22T04:26:14ZengElsevierSaudi Journal of Biological Sciences1319-562X2022-10-012910103404Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats Agussalim0Nafiatul Umami1 Nurliyani2Ali Agus3Department of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada. Jl. Fauna 3 Bulaksumur, Yogyakarta 55281, IndonesiaDepartment of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada. Jl. Fauna 3 Bulaksumur, Yogyakarta 55281, IndonesiaDepartment of Animal Products Technology, Faculty of Animal Science, Universitas Gadjah Mada. Jl. Fauna 3 Bulaksumur, Yogyakarta 55281, IndonesiaDepartment of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada. Jl. Fauna 3 Bulaksumur, Yogyakarta 55281, Indonesia; Corresponding author.Honey is rich in bioactive compounds, phenolic acids, and flavonoids and is an antioxidant and an immunomodulator. The objectives of this study were to determine the honey chemical composition of Indonesian stingless bees and their potential roles as an immunomodulator in the malnourished rats. Tetragonula laeviceps honey was used to analyses of chemical composition was obtained from three different geographical origins were Depok Sleman, Bayan Lombok, and Nglipar Gunungkidul. Thirty-two rats were divided into four groups of 8 rats and placed in individual cages. The experimental designed was as follows: T1 = normal rats + without honey (0–7 weeks), T2 = normal rats + with honey of 1.8 g/kg BW/day (0–7 weeks), T3 = malnourished honey of 1.8 g/kg BW/day started from 2 weeks after the malnourished condition (2–7 weeks). The results showed that the chemical composition of Tetragonula laeviceps honey from three different geographical origins were vitamin C content (6.49–13.58 mg/100 g), total phenolic content (0.65–2.30% GAE/100 g), total flavonoid content (0.28–1.00 mg QE/g), and antioxidant activity DPPH (61.43–90.28%). The application of fresh honey from stingless bee that was offered to either normal or malnourished rats were increased lymphocytes proliferation and decreased the production of both proinflammatory markers, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) from tissue culture supernatant of lymphocytes (p < 0.01). Data from this study clearly indicates the potential role of honey from stingless bee as an immunomodulator in malnourished rats.http://www.sciencedirect.com/science/article/pii/S1319562X22003205Anti-inflammatoryFlavonoidInterleukin-6PhenolicTumor necrosis factor-α |
| spellingShingle | Agussalim Nafiatul Umami Nurliyani Ali Agus Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats Saudi Journal of Biological Sciences Anti-inflammatory Flavonoid Interleukin-6 Phenolic Tumor necrosis factor-α |
| title | Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats |
| title_full | Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats |
| title_fullStr | Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats |
| title_full_unstemmed | Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats |
| title_short | Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats |
| title_sort | stingless bee honey tetragonula laeviceps chemical composition and their potential roles as an immunomodulator in malnourished rats |
| topic | Anti-inflammatory Flavonoid Interleukin-6 Phenolic Tumor necrosis factor-α |
| url | http://www.sciencedirect.com/science/article/pii/S1319562X22003205 |
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